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IRCT201201035144N3 IRCT 2013-06-25 Vice Chancellor for Research Ardabil University of Medical Sciences Consumption effects of conjugated linoleic acid (CLA) supplementation on oxidative stress and matrix metaloproteinases following exercise in young healthy males Consumption effects of conjugated linoleic acid (CLA) supplementation on oxidative stress and matrix metaloproteinases after exhaustive training in young healthy males men 2013-02-18 anticipated 30 Complete https://irct.ir/trial/5493 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Basic scienece. 2-3 Healthy trained individuals. Intervention 1: Given 5.6 gram/day CLA for14 days and once exhaustive exercise for intervention group. Intervention 2: Giving 5.6 gram oral Paraffin to control group for 14 days and once exhausting exercise.
public Seyedyashar Alamolhoda
Biochemistry Dept, Ardabil University of Medical Sciences, Ardabil University of Medical Sciences, Daneshgah Avenue, Ardabil, Iran.
Ardabil Iran (Islamic Republic of) 5155653466 +98 41 1657 8793 sy.alam@arums.ac.ir Ardabil University of Medical Sciences scientific Mohammad Mazani
Biochemistry Dept, Faculty of Medicine, Ardabil University of Medical Sciences, Daneshgah Avenue, Ardabil, Iran
Ardabil Iran (Islamic Republic of) 5618953141 +98 45 1551 2788 m.mazani@arums.ac.ir Ardabil University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: Young healthy males with moderate physical activity in 18-30 years old. Exclusion criteria: Individuals with certain diseases, smoking, alcoholism and other supplements, having certain dietary, professional training, sedentary and having 25<BMI<18.5 (body mass index)Kg/m2. 18 years 30 years Male Z02.5 Examination for participation in sport Other Placebo Given 5.6 gram/day CLA for14 days and once exhaustive exercise for intervention group. Giving 5.6 gram oral Paraffin to control group for 14 days and once exhausting exercise Exhaustion time. Timepoint: At the end of once training. Method of measurement: The signs and symptoms related to the complete exhaustion. Oral Paraffin. Timepoint: Two week. Method of measurement: Gram. Height. Timepoint: At the beginning of intervention. Method of measurement: Stadiometers. Weight. Timepoint: At the beginning of intervention. Method of measurement: Digital scales. Malondialdehyde. Timepoint: At the beginning of intervention, previous and after of exercise. Method of measurement: Spectrophotometry. Total antioxidant capacity. Timepoint: At the beginning of intervention, previous and after of exercise. Method of measurement: Spectrophotometry. Superoxide dismutase. Timepoint: At the beginning of intervention, previous and after of exercise. Method of measurement: Spectrophotometry. Glutathione peroxidase. Timepoint: At the beginning of intervention, previous and after of exercise. Method of measurement: Spectrophotometry. Ascorbic acid. Timepoint: At the beginning of intervention, previous and after of exercise. Method of measurement: Spectrophotometry. Catalase. Timepoint: At the beginning of intervention, previous and after of exercise. Method of measurement: Spectrophotometry. Matrix metalloproteinase-2. Timepoint: At the beginning of intervention, previous and after of exercise. Method of measurement: ELISA. Matrix metalloproteinase-9. Timepoint: At the beginning of intervention, previous and after of exercise. Method of measurement: ELISA. Interlukine-6. Timepoint: At the beginning of intervention, previous and after of exercise. Method of measurement: ELISA. Tumor Necrosis factor-alpha. Timepoint: At the beginning of intervention, previous and after of exercise. Method of measurement: ELISA. Hs-CRP. Timepoint: At the beginning of intervention, previous and after of exercise. Method of measurement: Immunoturbidimetry. Paraoxonase-1. Timepoint: At the beginning of intervention, previous and after of exercise. Method of measurement: Spectrophotometry. Fasting blood suger. Timepoint: At the beginning of intervention, previous and after of exercise. Method of measurement: Spectrophotometry. Arylesterase (ARE). Timepoint: At the beginning of intervention, previous and after of exercise. Method of measurement: Spectrophotometry. HDL-Cholesterol. Timepoint: At the beginning of intervention, previous and after of exercise. Method of measurement: Spectrophotometry. LDL-Cholesterol. Timepoint: At the beginning of intervention, previous and after of exercise. Method of measurement: Spectrophotometry. Triglyceride. Timepoint: At the beginning of intervention, previous and after of exercise. Method of measurement: Spectrophotometry. Urea. Timepoint: At the beginning of intervention, previous and after of exercise. Method of measurement: Spectrophotometry. Creatinine. Timepoint: At the beginning of intervention, previous and after of exercise. Method of measurement: Spectrophotometry. Uric acid. Timepoint: At the beginning of intervention, previous and after exercise. Method of measurement: Spectrophotometry. Bilirubin. Timepoint: At the beginning of intervention, previous and after of exercise. Method of measurement: Spectrophotometry. Calcium. Timepoint: At the beginning of intervention, previous and after exercise. Method of measurement: Spectrophotometry. Complete blood count, hemoglobin and hematocrit. Timepoint: At the beginning of intervention, previous and after exercise. Method of measurement: Cell counter. Copper. Timepoint: At the beginning of intervention, previous and after exercise. Method of measurement: Atomic absorptions spectrophotometry. Zinc. Timepoint: At the beginning of intervention, previous and after exercise. Method of measurement: atomic absorption spectrophotometry. Iron (Fe). Timepoint: At the beginning of intervention, previous and after exercise. Method of measurement: Spectrophotometry. Magnesium(Mg). Timepoint: At the beginning of intervention, previous and after exercise. Method of measurement: spectrophotometry. Ceruloplasmin(Cp). Timepoint: At the beginning of intervention, previous and after exercise. Method of measurement: Spectrophotometry. Phosphorus. Timepoint: At the beginning of intervention, previous and after of exercise. Method of measurement: Spectrophotometry. Leptin. Timepoint: At the beginning of intervention, previous and after of exercise. Method of measurement: ELISA. Total Cholesterol. Timepoint: At the beginning of intervention, previous and after of exercise. Method of measurement: Spectrophotometry. Total protein. Timepoint: At the beginning of intervention, previous and after of exercise. Method of measurement: Spectrophotometry. Creatine phosphokinase(CK). Timepoint: At the beginning of intervention, previous and after of exercise. Method of measurement: Spectrophotometry. Parathormone(PTH). Timepoint: At the beginning of intervention, previous and after exercise. Method of measurement: ELISA. Vice Chancellor for Research Ardabil University of Medical Sciences Approved 2013-02-18 Ethic Committee of Ardabil University of Medical Sciences Ethic Committee of Ardabil University of Medical Sciences, Vice Chancellor for Research, Ardabil University of Medical Sciences, Ardabil University of Medical Sciences, Daneshgah Avenue, Ardabil, Iran Ardabil Iran (Islamic Republic of)