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IRCT20131108015322N5 IRCT 2021-04-07 Shahid Beheshti University of Medical Sciences Effect of oral clonidine premedication on blood loss in total hip arthroplasty Comparison of the effect of oral clonidine premedication with placebo on perioperative blood loss in total hip arthroplasty surgery patients 2021-04-09 anticipated 34 Complete https://irct.ir/trial/55107 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: To assign patients to two groups, randomization is done by the block randomization method and concealed in sequentially numbered, sealed, opaque envelopes. In order to maintain a random sequence, the envelopes are numbered in the same way on the outer surface. Then envelopes are glued and placed inside the box, respectively. At the time of the assignment, according to the order of entry of eligible participants into the study, the relevant enveloper is opened in order and the assigned group of that participant is revealed, Blinding description: Participants, investigators, healthcare providers for participants and outcome assessors are kept blind. N/A Intraoperative and postoperative blood loss in total hip arthroplasty. Intervention 1: Intervention group: Patients receiving clonidine tablet. Intervention 2: Control group: Patients receiving placebo tablet. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information
public Shideh dabir
2nd floor, Department of Anesthesiology, Taleghani Hospital, Arabi St., Yaman St. Velenjak
Tehran Iran (Islamic Republic of) 1985717413 +98 21 2243 2595 shdabir@yahoo.com Shahid Beheshti University of Medical Sciences scientific Shideh dabir
2nd floor, Department of Anesthesiology, Taleghani Hospital, Arabi St., Yaman St. Velenjak
Tehran Iran (Islamic Republic of) 1985717413 +98 21 2243 2595 shdabir@yahoo.com Shahid Beheshti University of Medical Sciences Iran (Islamic Republic of) ASA class 1 and 2 patients Elective total hip arthroplasty Primary total hip arthroplasty 18 years 75 years Both ASA 3 and 4 patients Patients with BMI greater than 30 Patients with Hb less than 10 Patients with severe liver or kidney diseases Patients taking anticoagulants patients with coagulation disorders Alcoholic patients Revision total hip arthroplasty Patients with previous surgery in the operated area Treatment - Drugs Treatment - Drugs Intervention group: Patients receiving clonidine tablet Control group: Patients receiving placebo tablet The amount of bleeding during the operation. Timepoint: After intervention during surgery. Method of measurement: Weighing blood gases, amount of blood in the suction bottle, blood in the operative site. Postoperative hemoglobin level. Timepoint: On the first and third day after surgery. Method of measurement: Measured from a blood sample. Blood transfusion rate. Timepoint: During surgery and in the postoperative period. Method of measurement: Number of transfused units of blood. Shahid Beheshti University of Medical Sciences Approved 2021-01-31 Ethics committee of Shahid Beheshti University of Medical Sciences Arabi St., Yemen St., Velenjak, Shahid Beheshti University of Medical Sciences Tehran Tehran Iran (Islamic Republic of)