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IRCT20201223049804N2 IRCT 2021-04-07 Ahvaz University of Medical Sciences Evaluation of milk protein concentrate (MPC) on weight-loss Effect of milk protein concentrates (MPC) on serum levels of Orexin-A, Apelin, and TNF- α in obese women on a weight-loss diet 2022-04-10 anticipated 44 Complete https://irct.ir/trial/55342 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: The subjects will be randomly stratified according to age and BMI using a permuted block randomization procedure by Random Allocation Software (RAS). They will be assigned to one of the two study groups: (1) Standard weight loss group (n=22) (control group) (2) MPC supplementation weight loss group (n=22) (intervention group). N/A Obesity. Intervention 1: Intervention group: Isocaleric weight loss diet and milk protein concentration (MPC) powders will be prescribed. Each of intervention group subjects, will receive 30 gram milk protein concentration (MPC) powders per day. Intervention 2: Control group: will receive standard weight loss (macronutrients percent will be carbohydrate55%, fat 30% and 15% protein). Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is If the decision is to publicate the data, after the unidentified individuals all data will be publicated
public Mahsa Elahikhah
Golestan highway,ahvaz
Ahvaz Iran (Islamic Republic of) 1579461357 +98 61 3333 9092 mahsa.elahikhah@gmail.com Ahvaz University of Medical Sciences scientific Dr. Haidari Fatemeh
Golestan highway,ahvaz
Ahvaz Iran (Islamic Republic of) 1579461357 +98 61 3333 9092 haidari-f@ajums.ac.ir Ahvaz University of Medical Sciences Iran (Islamic Republic of) aged 18 years and older female BMI range of 30 to 40 kg/m2 absence of menopause, lactation and pregnancy no food allergies not having eating disorders, particularly binge eating disorder (BED), bulimia not having cancer, hepatic, renal, thyroid and gastrointestinal disorders no surgery for weight loss no weight loss over the past 6 months no taking herbs and drug that reduce appetite and weight and vitamin-mineral supplements 18 years 48 years Female become pregnant during study unwilling to continue changes in diet during the study period no consumption of powders exceed 10% of total administered powders E66.0 Obesity due to excess calories Treatment - Other Treatment - Other Intervention group: Isocaleric weight loss diet and milk protein concentration (MPC) powders will be prescribed. Each of intervention group subjects, will receive 30 gram milk protein concentration (MPC) powders per day. Control group: will receive standard weight loss (macronutrients percent will be carbohydrate55%, fat 30% and 15% protein). Orexin-A. Timepoint: Before and 2 months after the intervention. Method of measurement: Bloodletting. Apelin. Timepoint: Before and 2 months after the intervention. Method of measurement: Bloodletting. TNF-α. Timepoint: Before and 2 months after the intervention. Method of measurement: Bloodletting. Weight. Timepoint: Before and 2 months after the intervention. Method of measurement: Seca scale-kg. Ahvaz University of Medical Sciences Approved 2021-02-27 Ahvaz Jundishapur University of Medical Sciences Ahvaz-Gholestan Ahvaz Khouzestan Iran (Islamic Republic of)