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IRCT20200721048159N2 IRCT 2021-04-22 Khoram-Abad University of Medical Sciences The effect of herbal syrup in the treatment of COVID-19 Evaluation of the Effect of Herbal Syrup on Clinical Outcome of Inpatient with Moderate to Severe COVID-19 Patient 2021-05-04 anticipated 66 Complete https://irct.ir/trial/55368 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: In this study, the 4-tier randomized block method is used to randomly assign patients to two groups A ('intervention group') and group B (control group). To do this, first by considering the classes as the age range under 50 years and over 50 years within each class, a list of blocks is written and numbers are assigned to them. (AABB (1) - ABAB (2) -ABBA (3) -BBAA (4) - BABA (5) - BAAB (6)). Then, using a table of random numbers, the numbers between one to 6 (for example, 1,4,5, etc.) are randomly selected, and finally the list of treatment assignments will be formed based on a sequence of letters A and B, Blinding description: This study is a triple blind and the patient, the treatment evaluator, and the statistician are unaware of the experimental group. 3 COVID-19. Intervention 1: Intervention group: Receiving 15 cc daily, three times a day orally of herbal syrups (each 100 ml of syrup prepared from 10 grams of apples, 15 grams of Lonicera, 15 grams of hyssop and 9 grams of yarrow). Patients in this group receive a standard treatment regimen based on the national protocol. Intervention 2: Control group: The group receiving placebo syrup that is given daily in two divided doses. Patients in this group receive a standard treatment regimen based on the national protocol. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information
public Forouzan Ahmadpour
Khoram-Abad University of Medical Sciences, km 4 of Khorramabad road
Khorramabad Iran (Islamic Republic of) 381351698 +98 66 3312 0239 ahmadpourforoz@yahoo.com Khoram-Abad University of Medical Sciences scientific Forouzan Ahmadpour
Khoram-Abad University of Medical Sciences, km 4 of Khorramabad road
Khorramabad Iran (Islamic Republic of) 381351698 +98 66 3312 0239 ahmadpourforoz@yahoo.com Khoram-Abad University of Medical Sciences Iran (Islamic Republic of) Hospitalized patients suspected to COVID-19 infection who tested positive for PCR or despite the negative PCR test who have a strong clinical evidence plus typical radiographic sing of Covid19 that is difficult to justify their symptoms based on other diseases The presence of respiratory symptoms (including shortness of breath, pain and pressure in the chest) with or without fever equal to or greater than 38 degrees Celsius and SpO2 less than 93%. 18 years no limit Both Dissatisfaction with the company Discharge of a patient with a criterion other than recovery Admission to another interventional study Need to be admitted to the intensive care unit Occurrence of side effects such as hypersensitivity reactions G6PD deficiency Taking antiplatelet drugs, blood pressure medications, sedatives and barbiturates Receiving cardiac glycosides Hepatic-renal problems Cushing's syndrome Epilepsy U07.1 COVID-19, virus identified Treatment - Drugs Placebo Intervention group: Receiving 15 cc daily, three times a day orally of herbal syrups (each 100 ml of syrup prepared from 10 grams of apples, 15 grams of Lonicera, 15 grams of hyssop and 9 grams of yarrow). Patients in this group receive a standard treatment regimen based on the national protocol. Control group: The group receiving placebo syrup that is given daily in two divided doses. Patients in this group receive a standard treatment regimen based on the national protocol. Duration of hospitalization. Timepoint: Daily for 5-10 days. Method of measurement: Based on patient file information. The duration of recovery or the duration of entry into the disease stage. Timepoint: Daily for 5-10 days. Method of measurement: Based on patient file information. Survival rate of 28 days from the time of hospitalization. Timepoint: 28 days after starting the study. Method of measurement: Interview with the patient or her family. The amount of arterial oxygen saturation. Timepoint: Daily for 5-10 days. Method of measurement: Using a device to measure the percentage of oxygen saturation. Frequency of transfer to intensive care unit. Timepoint: Daily for 5-10 days. Method of measurement: Under supervision. Vice Chancellor for Research and Technology of Lorestan University of Medical Sciences Khoram-Abad University of Medical Sciences Vice Chancellor for Research and Technology of Lorestan University of Medical Sciences Approved 2020-12-05 Ethics committee of Lorestan University of Medical Sciences Office of Research Ethics Committee, Lorestan University of Medical Sciences, 3 km of Khorramabad Road, Tehran Khorramabad Lorestan Iran (Islamic Republic of)