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IRCT201011275181N3 IRCT 2012-01-12 Caspian Pharmaceutical Company Comparing the Oxytocin made in Iran with Oxytocin from foreign country for induction of labor A comparative study of the use of oxytocin (Iranian-made and foreign) in the induction of labor. 2011-04-09 anticipated 100 Complete https://irct.ir/trial/5549 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. 3 Long labor. Intervention 1: The group 1 (oxytocin), First 10 units oxytocin spilled in 1000 cc of blood Ringer (2/5mu/min) Then four drops per minute infusion rate 2 / 5 is increased to the maximum mu / min 40 in. The same amount will continue. After a good start uterine contractions, vaginal examination will be done if the patient Prom every hour and in rupture of the amniotic soc every 2 hour and every half hour inuterine contractions. mother's vital signs will be controlled before oxytocin induction and then each hour. If signs of fetal distress or uterine hyperstimulation appears, oxytocin is stopped. In an extreme case of improved The uterus stimulation and fetal distress, re-infusion with previous dose begins and continues with the same sequence. If 6 hours after induction does not change, the patient with pain induction is regarded as a failure of Bishop Score and Induction will be stopped But if you switch off the induction of cervical, induction continues. The rate of cervical dilatation and effacement during the induction phase of active labor and every 30 minutes every 15 minutes during the second stage of labor is controlled To determine the progress of labor. Intervention 2: The group 2 (oxytocip), First 10 units oxytocin spilled in 1000 cc of blood Ringer (2/5mu/min) Then four drops per minute infusion rate 2 / 5 is increased to the maximum mu / min 40 in. The same amount will continue. After a good start uterine contractions, vaginal examination will be done if the patient Prom every hour and in rupture of the amniotic soc every 2 hour and every half hour inuterine contractions. mother's vital signs will be controlled before oxytocin induction and then each hour. If signs of fetal distress or uterine hyperstimulation appears, oxytocin is stopped. In an extreme case of improved The uterus stimulation and fetal distress, re-infusion with previous dose begins and continues with the same sequence. If 6 hours after induction does not change, the patient with pain induction is regarded as a failure of Bishop Score and Induction will be stopped But if you switch off the induction of cervical, induction continues. The rate of cervical dilatation and effacement during the induction phase of active labor and every 30 minutes every 15 minutes during the second stage of labor is controlled To determine the progress of labor.
public
scientific Rashidi Batool
Imam Khomeini Hospital, Vali-Asr Hospital, Tehran University of Medical Sciences
Tehran Iran (Islamic Republic of) +98 21 6658 1616 bhrashidi@yahoo.com Vali-E-Asr Reproductive Health Research Center Iran (Islamic Republic of) Inclusion criteria: one Fetal pregnancy; Cephalic presentation; intact amniotic membrane; Reactive NST; less than 3 uterus contraction per 10 minutes. Exclusion criteria: regular contraction (more than 6 contraction per hours); fetal death; Amniotomy contra indication; mother age less than 18 years; previous C/S; Multiparty (>3); Chorioamniotit; Asthma history; Multiple gestation; Placenta previa; Non Cephalic presentation; Glucoma; Vaginal bleeding; sensitivity to Prostoglandin; irregular in fetal heart rate; contra indication of vaginal delivery. 18 years 40 years Female O63 Long labour Treatment - Drugs Treatment - Drugs The group 1 (oxytocin), First 10 units oxytocin spilled in 1000 cc of blood Ringer (2/5mu/min) Then four drops per minute infusion rate 2 / 5 is increased to the maximum mu / min 40 in. The same amount will continue. After a good start uterine contractions, vaginal examination will be done if the patient Prom every hour and in rupture of the amniotic soc every 2 hour and every half hour inuterine contractions. mother's vital signs will be controlled before oxytocin induction and then each hour. If signs of fetal distress or uterine hyperstimulation appears, oxytocin is stopped. In an extreme case of improved The uterus stimulation and fetal distress, re-infusion with previous dose begins and continues with the same sequence. If 6 hours after induction does not change, the patient with pain induction is regarded as a failure of Bishop Score and Induction will be stopped But if you switch off the induction of cervical, induction continues. The rate of cervical dilatation and effacement during the induction phase of active labor and every 30 minutes every 15 minutes during the second stage of labor is controlled To determine the progress of labor. The group 2 (oxytocip), First 10 units oxytocin spilled in 1000 cc of blood Ringer (2/5mu/min) Then four drops per minute infusion rate 2 / 5 is increased to the maximum mu / min 40 in. The same amount will continue. After a good start uterine contractions, vaginal examination will be done if the patient Prom every hour and in rupture of the amniotic soc every 2 hour and every half hour inuterine contractions. mother's vital signs will be controlled before oxytocin induction and then each hour. If signs of fetal distress or uterine hyperstimulation appears, oxytocin is stopped. In an extreme case of improved The uterus stimulation and fetal distress, re-infusion with previous dose begins and continues with the same sequence. If 6 hours after induction does not change, the patient with pain induction is regarded as a failure of Bishop Score and Induction will be stopped But if you switch off the induction of cervical, induction continues. The rate of cervical dilatation and effacement during the induction phase of active labor and every 30 minutes every 15 minutes during the second stage of labor is controlled To determine the progress of labor. Cesarian Section. Timepoint: at the end of induction of labor. Method of measurement: C/S or vaginal delivery. Duration of labor induction. Timepoint: Since the beginning of induction to delivery time. Method of measurement: Based on time. Duration of first labor period. Timepoint: begining of induction until delivery time. Method of measurement: based on hours. During the second stage of labor. Timepoint: Onset of contractions to full cervical dilatation. Method of measurement: Based on time. Uterine hyper stimulation. Timepoint: Time of contraction is more than two minutes. Method of measurement: Based on an specialist examination. Caspian Pharmaceutical Company Approved 2009-12-20 Vice Chancellor for Research,Tehran University of Medical Sciences Bulding of Vice Chancellor for Research, Ghods St., Keshavarz Blvd. Tehran Iran (Islamic Republic of)