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IRCT20201130049538N1 IRCT 2021-07-05 Razi University Short-term effect of vitamin D on liver enzymes and lipid profile in response to exhausting eccentric exercise Alterations of liver enzymes and lipid profile in response to exhausting eccentric exercise after short-term vitamin D supplementation in the overweight female with non-alcoholic fatty liver 2021-05-10 anticipated 30 Complete https://irct.ir/trial/55563 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Used, Assignment: Parallel, Purpose: Basic scienece, Randomization description: In this study, simple random sampling method will be used; And because the study population is small, the lottery method is used, That is, the names of the people are written on a piece of paper and placed inside the box, then the papers are taken out one by one until the desired sample size is complete, Blinding description: In this study, participants and health care personnel will be unaware of the type of intervention each patient receives. It should be noted that only the lead researcher will be aware of the intervention received for each patient. N/A Non-alcoholic fatty liver disease. Intervention 1: Intervention group: Fourteen subjects, Vitamin D supplementation (including receiving vitamin D from Zahravi Pharmaceutical Company, at the rate of 2000 units per day for six weeks), Exhaustive test and negative slope on the treadmill for two sessions (one session before supplementation and one session after supplementation), Control the intensity of exercise using a polar heart rate monitor and the Borg index, Blood sampling in four rounds. The first and second stages of sampling before and after the first training protocol and the third and fourth stages of sampling after the completion of the second training protocol. Intervention 2: Control group: Fourteen subjects, Receive a placebo containing paraffin made by Zahravi Pharmaceutical Company of Iran (daily for six weeks) which is similar to vitamin D supplement in terms of shape, color, smell and taste. Exhaustive test and negative slope on the treadmill for two sessions (one session before supplementation and one session after supplementation), Control the intensity of exercise using a polar heart rate monitor and the Borg index, Blood sampling in four rounds. The first and second stages of sampling before and after the first training protocol and the third and fourth stages of sampling after the completion of the second training protocol. Yes - There is a plan to make this available What will be shared: All data will be record in the SPSS software and will be available. When: Availability will start nine months after publishing all papers To whom: Only available for researchers in academic and scientific institutions Conditions: All data can be used as reference Where to obtain: zahra.rahimpour73@gmail.com How to obtain: If the explanation for data request would be convincing it will be given in 3 days. Comments: not having any
public Rastegar Hoseini
No.9, Taqh-Bostan Ave, University Blvd, Razi University.
Kermanshah Iran (Islamic Republic of) 6714967346 +98 83 3423 3267 R.hoseini@razi.ac.ir Razi Univeristy scientific Rastegar Hoseini
No.9, Taqh-Bostan Ave, University Blvd, Razi University.
Kermanshah Iran (Islamic Republic of) 6714967346 008334233267 R.hoseini@razi.ac.ir Razi University Iran (Islamic Republic of) Overweight women with non-alcoholic fatty liver Age 20 to 30 years Body mass index above 25 to 29.99 Detection of non-alcoholic fatty liver by ultrasound Vitamin D deficiency (25 levels of hydroxyvitamin D below 30 nanomoles / liter) 20 years 30 years Female Muscle injury Uncontrolled intake of vitamin D supplements Doing regular exercise smoking K76.0 Fatty (change of) liver, not elsewhere classified Lifestyle Lifestyle Intervention group: Fourteen subjects, Vitamin D supplementation (including receiving vitamin D from Zahravi Pharmaceutical Company, at the rate of 2000 units per day for six weeks), Exhaustive test and negative slope on the treadmill for two sessions (one session before supplementation and one session after supplementation), Control the intensity of exercise using a polar heart rate monitor and the Borg index, Blood sampling in four rounds. The first and second stages of sampling before and after the first training protocol and the third and fourth stages of sampling after the completion of the second training protocol. Control group: Fourteen subjects, Receive a placebo containing paraffin made by Zahravi Pharmaceutical Company of Iran (daily for six weeks) which is similar to vitamin D supplement in terms of shape, color, smell and taste. Exhaustive test and negative slope on the treadmill for two sessions (one session before supplementation and one session after supplementation), Control the intensity of exercise using a polar heart rate monitor and the Borg index, Blood sampling in four rounds. The first and second stages of sampling before and after the first training protocol and the third and fourth stages of sampling after the completion of the second training protocol. Lipid profile. Timepoint: Prior to the beginning and at the end of the study. Method of measurement: By blood sampling. Serum levels of liver enzymes. Timepoint: Prior to the beginning and at the end of the study. Method of measurement: By blood sampling. Glucose and insulin levels. Timepoint: Prior to the beginning and at the end of the study. Method of measurement: By blood sampling. Razi University Approved 2021-02-24 Ethics committee of Kermanshah Razi University No.9, Taqh-Bostan Ave, University Blvd, Razi University. Kermanshah Kermanshah Iran (Islamic Republic of)