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IRCT201605171310N10 IRCT 2016-10-13 Vice chancellor for research, Kermanshah University of Medical Sciences Comparison the effectiveness of burn drugs on controlling pain of burn patients Comparison the effect of Gabapentin, Ketamine, Entonox and Dexmedetomidine drugs in controlling pain of burn patients 2016-10-06 anticipated 100 Complete https://irct.ir/trial/556 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Other design features: Randomly by tossing coin. 2-3 burn. Intervention 1: The first intervention group will receive 1800 mg Gabapentin orally 2 hours before entering the operating room. Intervention 2: In the second intervention group ketamine in the form of intravenous in amount of 0.1 to 0.5 mg per kg of body weight will be given one minute before the start of surgery. Intervention 3: The third intervention group will receive Dexmedetomidine drug in the form of intravenous infusionand 0.1 to 0.5 mg per kilogram of body weight per minute in ten minutes before the start of surgery. Intervention 4: In the fourth intervention group five minutes before the start of surgery,Nitrous Oxide mixed with70% oxygen through a face mask is prescribed.
public Simin Chaghazardi
Emam Khomeini Hospital, Naghliyeh Street
Kermanshah Iran (Islamic Republic of) +98 83 3727 9104 siminchaghazardi@gmail.com Kermanshah University of Medical Sciences scientific Dr. Ali Reza Ahmadi
Emam Khomeini Hospital, Naghliyeh Street
Kermanshah Iran (Islamic Republic of) +98 83 3727 9104 ahmadiar1012@yahoo.com Kermanshah University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: age between 18 and 60 years; Burn with grade 2 and 3, burns 20 percent to 50 percent; AS A Class 1 and 2 Exclusion criteria: pregnant women; People with any known chronic mental illness; Patients with history of chronic underlying cardiac, lung and kidney disease; patients treated with certain medications such as immunosuppressive medications or chemotherapy or Corticosteroid 18 years 60 years Both T20 Burn and corrosion Treatment - Drugs Treatment - Drugs Treatment - Drugs Treatment - Drugs The first intervention group will receive 1800 mg Gabapentin orally 2 hours before entering the operating room. In the second intervention group ketamine in the form of intravenous in amount of 0.1 to 0.5 mg per kg of body weight will be given one minute before the start of surgery. The third intervention group will receive Dexmedetomidine drug in the form of intravenous infusionand 0.1 to 0.5 mg per kilogram of body weight per minute in ten minutes before the start of surgery In the fourth intervention group five minutes before the start of surgery,Nitrous Oxide mixed with70% oxygen through a face mask is prescribed. The amount of pain. Timepoint: Beginning of the study, half an hour, an hour, two hours, four hours, six hours after start of surgery. Method of measurement: Using visual analogue scale (VAS). Vice chancellor for research, Kermanshah University of Medical Sciences Approved 2016-07-13 Ethics committee of Kermanshah University of Medical Sciences Building No.2, Shahid Beheshti, Vice Chancellor for Research Affairs, Kermanshah University of Medical Sciences Kermanshah Iran (Islamic Republic of)