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IRCT20120701010149N3 IRCT 2021-05-01 Esfahan University of Medical Sciences The effect of curcumin on rheumatoid arthritis The effect of curcumin-piperine supplementation on anthropometric indices and clinical signs in patients with rheumatoid arthritis A double-blind clinical trial study 2021-05-04 anticipated 60 Complete https://irct.ir/trial/55680 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Basic scienece, Randomization description: They will be randomly divided into one of two groups of intervention and placebo and will be studied for 12 weeks. The intervention group will receive a daily capsule containing curcumin piperine (containing 500 mg of curcumin extract and 5 mg of piperine) and the control group will receive a daily placebo capsule (500 mg of maltodextrin) with diet and exercise recommendations; The recommendations are the same in both groups, Blinding description: In order to conduct this research in a double-blind manner, before starting the study, the total capsules are coded in A and B by a person other than the researcher, so that both groups do not know the type of capsules received by both groups. To track that individuals in the study groups use the capsules. 3 Rheumatoid Arthritis. Intervention 1: Intervention group: Patients receiving one 500 mg capsule per day of curcumin-piperine (500 mg curcumin-5 mg piperine) per day for 12 weeks (30 patients). Intervention 2: Control group: Patients receiving 1 placebo capsule containing 500 mg maltodextrin daily for 12 weeks (30 patients). Yes - There is a plan to make this available What will be shared: All data can be shared at the request of individuals When: Six months after publishing the results. To whom: Academic researchers Conditions: Scientific uses Where to obtain: By sending an email to the following address that belongs to the executor of the project: motaghi@med.mui.ac.ir How to obtain: Clear request on the site to access the data by the individual and then review the request by the research assistant within 2 weeks and then allow access to the data. Comments:
public peiman motaghi
Azadi Square, Hezar Jarib St., Isfahan University of Medical Sciences
Isfahan Iran (Islamic Republic of) ۸۱۷۴۶۷۳۴۶۱ +98 31 3620 2020 motaghi@med.mui.ac.ir Esfahan University of Medical Sciences scientific پیمان متقی
Azadi Square, Hezar Jarib St., Isfahan University of Medical Sciences
Isfahan Iran (Islamic Republic of) ۸۱۷۴۶۷۳۴۶۱ +98 31 3620 2020 motaghi@med.mui.ac.ir Esfahan University of Medical Sciences Iran (Islamic Republic of) Willingness to participate in the study Age 20-60 years Rheumatoid arthritis according to the rheumatologist according to the American College of Rheumatology 2010, the disease activity score is higher than 1/5 and the total soft joint count (TJC) and swollen joint count (SJC) is higher than 8. 20 years 60 years Both Pregnancy and lactation Smoking Heart, lung and kidney disease, hepatitis, cirrhosis, biliary and immune system disorders, hypertension, diabetes, hypothyroidism, Cushing's syndrome M05 Rheumatoid arthritis with rheumatoid factor Treatment - Drugs Placebo Intervention group: Patients receiving one 500 mg capsule per day of curcumin-piperine (500 mg curcumin-5 mg piperine) per day for 12 weeks (30 patients) Control group: Patients receiving 1 placebo capsule containing 500 mg maltodextrin daily for 12 weeks (30 patients) Symptoms. Timepoint: Beginning and end of the study. Method of measurement: Symptoms will be measured using the Disease Activity Score of 28 joints (DAS ‐ 28). Soft joint count (TJC) and swollen joint count (SJC) are determined by a rheumatologist. Esfahan University of Medical Sciences Approved 2021-01-24 Ethics Committee of Isfahan University of Medical Sciences Azadi Square, Hezar Jarib St., Isfahan University of Medical Sciences Isfahan Isfehan Iran (Islamic Republic of)