IRCT20150802023468N7 IRCT 2021-05-19 Hamedan University of Medical Sciences Evaluation the effect of gum containing petal extract of crocus sativus on gingival inflammation Evaluation of the effect of gum containing petal extract of crocus sativus on gingival inflammation in fixed orthodontic patients 2021-05-31 anticipated 32 Complete https://irct.ir/trial/55770 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: The randomization method is block by size 4 blocks. Randomization is performed using a table of random numbers, Blinding description: The participant and the investigator are both blind. Chewing gum packaging is similar to the comparison and intervention group. 3 gingivitis. Intervention 1: Intervention group: The hydroalcoholic extract of Crocus sativus petal plant was extracted by soaking method and dried and concentrated by rotary distillation in vacuum, then gum containing Crocus sativus was produced in Mana and Dana factory with acceptable concentration. Patients use chewing gum twice a day for two months after each brushing. Intervention 2: Control group: Placebo chewing gum was produced in Mana and Dana factories without any extract. Patients use chewing gum twice a day for two months after each brushing. No - There is not a plan to make this available Justification or reason for not sharing IPD is "There is no further information"