IRCT20160524028038N11 IRCT 2021-04-29 Yasouj University of Medical Sciences Oral probiotics and cerclage The effect of oral probiotics on pregnancy outcomes in pregnant women undergoing cerclage compared with placebo 2020-09-24 anticipated 104 Complete https://irct.ir/trial/55864 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Randomization method: use block; Random unit: Individual; Randomization tool: Statistical software; Sequence Building: Using randomized in 4 blocks; Hiding method: Use envelopes in the package. N/A Cervical insufficiency. Intervention 1: Intervention group(cerclage plus lactofem): Lactofem capsule (500 mg) made by Iranian zist-takhmir Company will be administered orally and daily from the day of cerclage until the end of pregnancy. Intervention 2: Control group (cerclage with placebo): Placebo drug is very similar to group A with the same method, the duration of treatment will be prescribed. The placebo drug will be prepared by Medicinal Plants Laboratory, Yasouj University of Medical Sciences similar to probiotics. No - There is not a plan to make this available Justification or reason for not sharing IPD is No more information