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IRCT20150825023753N19 IRCT 2023-11-04 Shiraz University of Medical Sciences Evaluation of efficacy of intramuscular injection of pantothinic acid in patients with mild to moderate acne Evaluation of efficacy of intramuscular injection of pantothinic acid in patients with mild to moderate acne referred to dermatology clinics 2023-11-06 anticipated 60 Complete https://irct.ir/trial/56032 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Other design features: In this plan, placebo is not used and each group will be prescribed a different medicine with the purpose of treatment, Randomization description: By using random allocation software, consecutive permutation blocks with the size of 6 people in each block are made and the patients are divided into two groups A (first treatment method) and B (second treatment method), Blinding description: Due to the clear difference in the treatment method and the different drug form in each study group, blinding is done only at the level of the outcome assessor. 3 Acne. Intervention 1: Intervention group: The first group is treated with dexpanthenol 500 mg ampoule manufactured by Actover pharmaceutical company, one intramuscular injection and adapalene gel per week. Intervention 2: Control group: The second group will only be treated with adapalene gel topically every other night. Yes - There is a plan to make this available What will be shared: Demographic data and the result of the clinical trial When: One year later To whom: Researchers Conditions: After publication of the extracted article of the clinical trial Where to obtain: Sending Email to the researchers How to obtain: Sending the request via email Comments:
public Fahimeh Mohammadi, MD
Zand Avenue, Shahid Faghihi Hospital
Fars Iran (Islamic Republic of) 7134846114 +98 71 3235 1087 fahimeh.mohammadi8606@gmail.com Shiraz University of Medical Sciences scientific Nasrin Saki, MD
Zand Avenue, Shahid Faghihi Hospital
Shiraz Iran (Islamic Republic of) 7134846114 +98 71 3235 1087 nasrinsa85@yahoo.com Shiraz University of Medical Sciences Iran (Islamic Republic of) Iran (Islamic Republic of) Patients with mild to moderate acne Patients have not received any systemic treatment in the last one month and have not received any local treatment in the last two weeks Married women who agree to use physical methods of contraception such as condoms and IUDs during the study 16 years 40 years Both Pregnant and lactating women Patients with polycystic ovary syndrome Lack of consent to continue studying Use of herbal medicines History of allergy to the studied drug Allergy to adapalene gel Inability to visit regularly to check response to treatment Patients with severe acne Existence of systemic disease including kidney and liver problems Current use of dietary supplements for skin health L70.0 Acne vulgaris Treatment - Drugs Treatment - Drugs Intervention group: The first group is treated with dexpanthenol 500 mg ampoule manufactured by Actover pharmaceutical company, one intramuscular injection and adapalene gel per week. Control group: The second group will only be treated with adapalene gel topically every other night Acne severity. Timepoint: Base line, first month, second month. Method of measurement: Acne severity GAGS (Global Acne Grading System). Quality of life of the patients. Timepoint: Base line, first month, second month. Method of measurement: Dermatology Quality of Life Index. Acne count. Timepoint: Base line, first month, second month. Method of measurement: Counting the acne lesions. Shiraz University of Medical Sciences Approved 2023-08-12 Ethics committee of Medical School of Shiraz University of Medical Sciences Medical School of Shiraz University of Medical Sciences Shiraz Fars Iran (Islamic Republic of)