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IRCT20200127046282N3 IRCT 2021-06-06 Skin and Stem cell Research Center of Tehran University of Medical Sciences Evaluation of clinical improvement of conditioned media of adipose derived stem cells in the treatment of wrinkles in the whole facial skin Title : Evaluation of clinical improvement of wrinkles in the whole facial skin using radiofrequency microneedling with adipose derived stem cell-conditioned medium 2021-07-21 anticipated 10 Complete https://irct.ir/trial/56039 interventional Randomization: Not randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Blinding description: In each session, immediately after the micro needling on one side of the face, the conditioned media of adipose derived stem cells and the other side of the face saline solution is used topically on the wrinkles. 1 Skin aging. Intervention 1: Control group: (Other side of face) After sufficient anesthesia, first treatment with micro needling, and then physiological serum is applied topically to the site of the wrinkles for one hour. This procedure is repeated 4 times with intervals of 4 weeks. . Intervention 2: Intervention group: One side of the face after being anesthetized, is first treated with micro needling, and then adipose conditioned media of adipose derived stem cells is applied topically to the wrinkles for one hour. This procedure is repeated 4 times with intervals of 4 weeks. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is I haven't decided yet - the release schedule is still unknown
public Sona Zare
No 4, Maryam Alley, South Kamraniyeh Street, Tehran, Iran
Tehran Iran (Islamic Republic of) 1937957511 +98 21 2221 5558 sonazarebio@gmail.com Skin and Stem cell Research Center of Tehran University of Medical Sciences scientific Mohammad Ali Nilforoushzadeh
No 4, Maryam Alley, South Kamraniyeh Street, Tehran, Iran
Tehran Iran (Islamic Republic of) 1937957511 +98 21 2221 5558 Dr_nilforoush@yahoo.com Skin and Stem cell Research Center of Tehran University of Medical Sciences Iran (Islamic Republic of) Age between 20-60 Having middle wrinkles in face region 20 years 60 years Both Pregnancy and breastfeeding History of cancer Patients with a new history of gel and Botox injections People with Mental Disorders Active infection in the face L90.9 Atrophic disorder of skin Treatment - Other Treatment - Other Control group: (Other side of face) After sufficient anesthesia, first treatment with micro needling, and then physiological serum is applied topically to the site of the wrinkles for one hour. This procedure is repeated 4 times with intervals of 4 weeks. . Intervention group: One side of the face after being anesthetized, is first treated with micro needling, and then adipose conditioned media of adipose derived stem cells is applied topically to the wrinkles for one hour. This procedure is repeated 4 times with intervals of 4 weeks. The amount of wrinkles. Timepoint: Before treatment and one month after the last session. Method of measurement: Visio face. Side effects. Timepoint: One week after session. Method of measurement: Questionnaire and visit. Skin and Stem cell Research Center of Tehran University of Medical Sciences Approved 2020-11-14 Research Ethics Committee of Tehran University of Medical Sciences Keshavarz blvd, Tehran University of Medical Sciences Tehran Tehran Iran (Islamic Republic of)