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IRCT20210415050976N5 IRCT 2021-06-22 Jahrom University of Medical Sciences Comparison of ketamine and dexmedetomidine in maintenance anesthesia Comparison of Ketamine and Dexmedetomidine in Maintenance of Anesthesia with Bispectral Index Scale during General Anesthesia 2021-09-01 anticipated 90 Complete https://irct.ir/trial/56167 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: In this study, block randomization method is used. With the help of the online site (www.sealedenvelope.com/simple-randomiser/v1/lists) randomization, 8 blocks of 15 are created. In each block, randomly classified, 5 patients are assigned to the ketamine group, 5 patients to the dexmedetomidine group, and 5 patients to the control group, Blinding description: For blinding, in the present study, the double-blind method is used so that the person reviewing the results and the person performing the injections do not know which patient received dexmethomedin and ketamine. 3 General anesthesia. Intervention 1: Intervention group 1: Dexmedetomidine infusion dose of 0.5 to 1 macro / kg body weight per hour will be administered during general anesthesia. The drug dexmedetomidine is used under the brand name Seddox, owned by Themis Medicare, and the vial of NDCC contains 200 micrograms of dexmedetomidine. Intervention 2: Intervention group 2: Ketamine infusion dose of 25. Up to 0.5 macro / kg body weight per hour will be administered during general anesthesia. Ketamine used is made by Pfizer company in Germany and its ampoule contains 10 cc of 500mg solution. Intervention 3: Control group: Simultaneously with anesthesia, a bolus dose of distilled water will be given as a placebo. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information.
public Navid Kalani
Jahrom, Shahid Motahari Boulevard
Jahrom Iran (Islamic Republic of) 7167758256 +98 71 2536 5231 k.navid@jums.ac.ir Jahrom University of Medical Sciences scientific Navid Kalani
Jahrom, Shahid Motahari Boulevard 7167758256
Jahrom Iran (Islamic Republic of) 7167758256 +98 71 2536 5231 k.navid@jums.ac.ir Jahrom University of Medical Sciences Iran (Islamic Republic of) Being an NPO for 8 hours ASA class one or two Satisfaction with general anesthesia 20 years 70 years Both High blood pressure Severe cardiovascular disease Severe dysfunction of the liver and kidneys A21.7 Generalized tularemia Treatment - Drugs Treatment - Drugs Placebo Intervention group 1: Dexmedetomidine infusion dose of 0.5 to 1 macro / kg body weight per hour will be administered during general anesthesia. The drug dexmedetomidine is used under the brand name Seddox, owned by Themis Medicare, and the vial of NDCC contains 200 micrograms of dexmedetomidine. Intervention group 2: Ketamine infusion dose of 25. Up to 0.5 macro / kg body weight per hour will be administered during general anesthesia. Ketamine used is made by Pfizer company in Germany and its ampoule contains 10 cc of 500mg solution. Control group: Simultaneously with anesthesia, a bolus dose of distilled water will be given as a placebo. Depth of anesthesia. Timepoint: After induction of anesthesia by an observer until the end of anesthesia will continue every 15 minutes. Method of measurement: Cerebral State Monitor device made by Donmeter.dk company from Denmark and electrocardiographic electrodes will be used. The pain. Timepoint: After surgery in recovery. Method of measurement: Pain is assessed according to the ruler criteria. Frequent nausea and vomiting. Timepoint: In recovery. Method of measurement: Based on the frequency of nausea and vomiting. Jahrom University of Medical Sciences Approved 2019-10-09 Ethics Committee of Jahrom University of Medical Sciences Jahrom, Shahid Motahari Boulevard, Jahrom University of Medical Sciences, Vice Chancellor for Research Jahrom Fars Iran (Islamic Republic of)