IRCT20101211005362N27 IRCT 2022-01-22 Esfahan University of Medical Sciences The effect of ondansetron and dexmedetomidine in reducing nausea and vomiting Comparative study of the preemptive Dexmedetomidine with Ondansetron effect in reducing the post-operative nausea and vomiting after elective middle ear surgery under general anesthesia 2021-11-22 anticipated 165 Complete https://irct.ir/trial/56239 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention, Randomization description: 165 people are selected by easy random method. The way to randomize is that anesthesiologist from a dark-colored bag containing 165 cards with titles O ( Ondansetron), D ( Dexmedetomidine), P ( placebo) that there are 55 of each card, and according to the card that is picked up the patient enters the investigation. (Output card will not be replaced), Blinding description: Drug injections are performed by an anesthesiologist without knowing the contents of the syringes. (Also, all syringes have the same color and volume). The way to randomize is that anesthesiologist from a dark-colored bag containing 165 cards with titles O ( ondansetron), D ( dexmedetomidine), P ( placebo) that there are 55 of each card, and according to the card that is picked up The patient enters the investigation.(Output card will not be replaced). Patients also do not know about the medication they are receiving. 3 Post operative nausea and vomiting. Intervention 1: Intervention group: they receive 0/1 mg per kg ondansetron in 10 cc normal saline in 10 minute. Intervention 2: Control group: 10 cc normal saline in 10 minute. Intervention 3: Intervention group: they recieve 1 microgram per kilogram in 10 cc normal saline in 10 minute. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is no more information