IRCT20210511051267N1 IRCT 2021-06-22 Hamedan University of Medical Sciences Comparison of Therapeutic Effect of Amantidine and Modafinil in Fatigue Related Multiple Sclerosis MS Comparison of Therapeutic Effect of Amantidine and Modafinil in Fatigue Related Multiple Sclerosis Patients in Hamedan M.S Clinic (Neshat) 2021-07-21 anticipated 150 Complete https://irct.ir/trial/56243 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: For randomization, we will use the method of balanced block randomization (block size: Four). For this purpose, we prepare four sheets of paper. On the two sheets, we write the I meaning "Intervention" and on the other two sheets we write the P meaning "Placebo". Mix the sheets together, and place them on the desk drawer. When referring to any of the eligible patients, one of the sheets was randomly taken out and based on this sheet, I or P was assigned to one of the two groups of intervention (Modafinil recipient) or comparison (Amantadine recipient). Extracted tabs will not be returned to the drawer until all four tabs have been extracted. After randomly pulling out all four sheets, all the sheets are returned to the drawer and the above procedure will be continued for the next four patients until the desire sample size (150 patients) is reached, Blinding description: The Executors of the research project (Attend and evaluating neurology resident) and statistical analysis colleague and also the patients will be unaware of the types of the drugs for each treatment group. 2 Fatigue related to multiple sclerosis. Intervention group:treatment groups. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information.