]>
IRCT20210513051276N1 IRCT 2021-06-03 Esfahan University of Medical Sciences The effect of finasteride and hydroxy chloroquine on frontal fibrosing alopecia Clinical trial of Comparison of the efficacy and safety of finasteride and hydroxy chloroquine on frontal fibrosing severity index in patients with frontal fibrosing alopecia 2021-06-21 anticipated 30 Complete https://irct.ir/trial/56264 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Sampling is performed among patients referred to dermoscopy clinic affiliated to the esfahan university of medical science and if they have the conditions to enter and leave the study are considered as an sample. Random function of Excel software based on patient file number will be used for randomization. Patients with frontal fibrosis alopecia are entered in Excel according to the file number and are divided into two groups of finasteride and hydroxychloroquine based on the random button. Once the file numbers are entered in Excel, then select the repeating each number option and select 15 repeating the sequence. In this way, 30 will be produced. Then, from the data analysis command, the random number is selected. It is clear that the repetition of each number occurs once in each group, for a total of two groups of 15 people. 2 Frontal fibrosing alopecia. Intervention 1: A group of 15 patients are treated with finasteride tablets of 2.5 mg daily for 6 months. Intervention 2: Intervention group: A group of 15 patients treated with hydroxychloroquine 400 mg daily for 6 months. Yes - There is a plan to make this available What will be shared: Dissemination of data that has nothing to do with the personality and identity of the participants in the study and are merely the consequences of the study. When: Start the access period after the article is published To whom: The data will be available only to researchers working in academic and scientific institutions, after their authentication by the relevant university. Conditions: The data can only be used for research and writing review articles. Where to obtain: The author will be available via the email and university phone number mentioned in the article. How to obtain: Access to the data is granted if it is found that the data has been requested for non-industrial and non-commercial use. Comments:
public Maryam Farokhshah
Alzahra Hospital, Dermatology Department, Sofeh Street, Isfahan, Iran
Esfahan Iran (Islamic Republic of) 8174645731 +98 31 3669 5414 Farokhshahimaryam@gmail.com Esfahan University of Medical Sciences scientific Maryam Farokhshahi
Alzahra Hospital, Dermatology Department, Sofeh Street, Isfahan, Iran
Esfahan Iran (Islamic Republic of) 8174645731 +98 31 3669 5414 Farokhshahimaryam@gmail.com Esfahan University of Medical Sciences Iran (Islamic Republic of) New cases with FFA who have not yet received any medication. Patients who have previously received systemic therapy and have not received systemic medication for at least the last three months and according to clinical and dermoscopic criteria, their disease is active. Patients treated with topical medication and according to clinical and dermoscopic criteria, their disease is active no limit no limit Both Pregnancy or lactation History of hypersensivity due to hydroxychloroquine or finasteride Patients with severe blood dyscrasia and liver dysfunction Patients with retinopathy Personal history or family history of breast cancer L66.9 Cicatricial alopecia, unspecified Treatment - Drugs Treatment - Drugs A group of 15 patients are treated with finasteride tablets of 2.5 mg daily for 6 months. Intervention group: A group of 15 patients treated with hydroxychloroquine 400 mg daily for 6 months. Frontal fibrosing alopecia severity index. Timepoint: Before and after intervention. Method of measurement: Checklist. Standardized global photography. Timepoint: Before and after intervention. Method of measurement: Based on scoring by two dermatologist. Tricoscopy. Timepoint: Before and after intervention. Method of measurement: Based on scoring by two dermatologist. Esfahan University of Medical Sciences Approved 2021-03-19 Ethics committee of Esfahan University of Medical Sciences AL Zahra Hospital, Dermatology Department, Sofeh Street, Isfahan, Iran Esfahan Isfehan Iran (Islamic Republic of)