IRCT20161126031095N2 IRCT 2021-07-13 Mazandaran University of Medical Sciences Comparison of the additive effect of dexmedetomidine and neostigmine to bupivacaine on pain intensity after cesarean section with spinal anesthesia Comparison of the additive effect of dexmedetomidine and neostigmine to bupivacaine on pain intensity after cesarean section with spinal anesthesia 2020-11-21 anticipated 110 Complete https://irct.ir/trial/56460 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Supportive, Randomization description: Randomization is done by randomized block method with various block sizes (multiples of 2). The unit is individual and is made by statistical software and delivered in a sealed envelope, Blinding description: The facilitator, the senior assistant performing spinal anesthesia, and the anesthesist present at the patient's bedside, as well as the first-year assistant filling out research forms were kept blind for each patient' administered drugs. The drugs were the same color and volume in the same syringes that could not be differentiated by the above individuals. 2 Other acute postprocedural pain. Intervention 1: Intervention group1: 1 microgram of dexmedetomidine is equivalent to a volume of 0.5 ml plus 2.5 ml of 0.5% bupivacaine. As a result, the total injection volume in each sample is 3 ml, which have the same color and shape. No. 25 and is performed from the lumbar intervertebral space in the cerebrospinal fluid. Intervention 2: Intervention group2:10 micrograms of neostigmine is equivalent to a volume of 0.5 ml plus 2.5 ml of 0.5% bupivacaine. As a result, the total injection volume in each sample is 3 ml, which have the same color and shape. Spinal cord No. 25 and is performed from the lumbar intervertebral space in the cerebrospinal fluid. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is I have not decided yet