IRCT201203225283N3 IRCT 2012-06-28 Women's Reproductive Health Research Center, Tabriz University of Medical Sciences Comparison the results of combination platinium based neoadjuvant chemotherapy regimens using gemcitabin/ciplatin with carboplatin/paclitaxel in advanced stage ovarian cancer patients; A RCT Comparison the results of combination platinium based neoadjuvant chemotherapy regimens using gemcitabin/ciplatin with carboplatin/paclitaxel in advanced stage ovarian cancer patients; A RCT 2009-11-22 anticipated 206 Complete https://irct.ir/trial/5654 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention. N/A Patients with advanced serous ovarian cancer, Figo stage III and IV. Intervention 1: For first group, at first daycombination ofgemcitabin (1000 mg per square meter on days 1 and 8 IV during 30 minutes) and cisplatin (75 mg per square meter, IV) are administrated. This protocol can be repeated every 21 days. This protocol is repeated every 21 days, and up to 3 courses of chemotherapy is done. Then patients undergo immediate interval debulking surgery. Intervention 2: For group 2, combination of carboplatin (carboplatin at an area under the concentration-time curve (AUC) of 5-6 mg/mL/min IV over 1 hour and paclitaxel (175 mg per square meter IV over 3 hours) on the first day will be prescribed. This protocol is repeated every 21 days, and up to 3 courses of chemotherapy is done. Then patients undergo immediate interval debulking surgery.