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IRCT20190606043826N2 IRCT 2021-07-01 Esfahan University of Medical Sciences Comparison of the effectiveness and complication of dexamethasone at doses of 8 and 24 mg in the treatment of in Hospitalized Patients with Covid-19 Comparison of the effectiveness and complication of dexamethasone at doses of 8 and 24 mg in the treatment of in Hospitalized Patients with Covid-19 2021-07-06 anticipated 60 Complete https://irct.ir/trial/56665 interventional Randomization: Not randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Blinding description: Participants (they have no information about the type of drug injected) Responsible for data collection (on the data collection sheet, the name of the type of drug received by the patient is not mentioned) Data analyzer (in the data sent to the analyzer, the treatment groups are listed as A and B). 3 covid 19 pneumonia. Intervention 1: Intervention group: Patients with covid 19 treated with dexamethasone 24 mg daily for 3 days and then 8 mg daily for 10 days or until discharge. Intervention 2: Control group: Patients with Covid 19 who are treated with dexamethasone 8 mg daily for 10 days or discharge time. Yes - There is a plan to make this available What will be shared: All data is potentially shareable after unidentified individuals When: After analyzing the results, the data access period is free To whom: Academic Institutions and Researchers Conditions: For use in future studies. Where to obtain: Corresponding Author How to obtain: Send an email to the author and get the information Comments:
public Somayeh Sadeghi Haddad Zavareh
Isfahan University of Medical Sciences and Health Services, Hezar Jerib St
Isfahan Iran (Islamic Republic of) 8174673461 +98 31 3668 0048 S.sadeghi117917@gmail.com Esfahan University of Medical Sciences scientific Somayeh Sadeghi Haddad Zavareh
Isfahan University of Medical Sciences and Health Services, Hezar Jerib St
Isfahan Iran (Islamic Republic of) 8174673461 +98 31 3668 0048 S.sadeghi117917@gmail.com Esfahan University of Medical Sciences Iran (Islamic Republic of) Hospitalized Patients with Covid-19 18 years no limit Both Pregnancy Immunodeficiency diseases chronic liver and kidney diseases or gastrointestinal bleeding Glucocorticoid use in the last 1 month u10 Multisystem inflammatory syndrome associated with COVID-19 Treatment - Drugs Treatment - Drugs Intervention group: Patients with covid 19 treated with dexamethasone 24 mg daily for 3 days and then 8 mg daily for 10 days or until discharge Control group: Patients with Covid 19 who are treated with dexamethasone 8 mg daily for 10 days or discharge time Determination of mean arterial blood oxygen saturation with and without oxygen therapy. Timepoint: At the beginning of hospitalization and 3, 5, 7 and 10 days later. Method of measurement: pulse oxymeter. Shortness of breath score based on modified Borg scale. Timepoint: At the beginning of hospitalization and 3, 5, 7 and 10 days later. Method of measurement: modified Borg scale. Number of days required for mechanical ventilation. Timepoint: daily. Method of measurement: Counting days under mechanical ventilation. Measurement of serum levels of C-reactive protein. Timepoint: At the beginning of hospitalization and 3, 5, 7 and 10 days later. Method of measurement: laboratory test. Vice Chancellor for Research, Isfahan University of Medical Sciences Approved 2021-05-29 Ethics committee of Isfahan University of Medical Sciences Isfahan University of Medical Sciences and Health Services, Hezar Jerib St Isfahan Isfehan Iran (Islamic Republic of)