IRCT20190624043991N14 IRCT 2021-06-18 Tehran University of Medical Sciences Evaluation of the specific bacteriophages to control of E.coli Evaluation of the specific bacteriophages to control of E.coli in patients with antibiotic-resistant urinary tract infections 2021-07-07 anticipated 20 Complete https://irct.ir/trial/56732 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Other design features: -, Randomization description: The present study is a double-blind randomized clinical trial. For randomization, the blanced block randomization method is used to generate four blocks. Intervention group A and control group B have been determined. According to the randomization method, we expect the two groups to differ by a maximum of 2 people in terms of the number of people assigned. After the methodologist prepares the randomization sequence using the sealdenvelop (for create a randomisation list) online site, the generated sequence will be made available to a technician outside the research team. Quadruple blocks (A or B) are placed in envelopes. After the arrival of the first patient with the inclusion criteria, the envelopes are randomly selected and the type of patient group is informed to the research team through a trained technician. The patient is placed in Control group: Rinsing the bladder with physiological saline with 20 cc of phosphate buffer salt (PBS) or Intervention group: Rinsing the bladder with physiological saline with 20 cc of Purified specific bacteriophage based on the randomly selected envelope, Blinding description: Patients who have agreed to participate in the study and the therapist for the blinding process, envelopes related to the type of intervention are provided only to the technician. The physician (to avoid bias) and the patient are not informed of the type of intervention (physiological saline plus phosphate buffer salt or physiological saline plus Purified specific bacteriophage). N/A Urinary tract infection. Intervention 1: Control group: Rinsing the bladder with physiological saline with 20 cc of phosphate buffer salt (PBS), Twice a week for three consecutive months. Intervention 2: Intervention group: Rinsing the bladder with physiological saline with 20 cc of Purified specific bacteriophage, Twice a week for three consecutive months. Yes - There is a plan to make this available What will be shared: demographic information anonymously When: one year after publication To whom: Researchers working in academia, physicians, surgeons and hospitals Conditions: Any analysis can be done with the consent of the main researcher Where to obtain: Sina Hospital, Urology Research Center, Head of Urology Research Center: Dr. Seyed Mohammad Kazem Aghamir 00982166348560 How to obtain: After reviewing the information by the administrator and epidemiologist, the patient information will be available for the applicant by the provision of a patient's privacy. Comments: -