]>
IRCT20210613051560N1 IRCT 2021-12-20 Zanjan University of Medical Sciences Endotracheal epinephrine effect on COVID-19 Evaluation of endotracheal epinephrine effect on Increasing Oxygen Saturation level in COVID-19 patients with severe pulmonary involvement 2021-12-22 anticipated 30 Complete https://irct.ir/trial/56858 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Simple randomization will perform on eligible patients using intratracheal epinephrine or intratracheal normal saline in every other manner. From the beginning, it is agreed to assign individual numbers to the intervention group and even numbers to the control group. Then extract the random sample size from the table of random numbers and assign each number (odd number to the first patient and even number to the second patient) to each patient. In other words, the first patient to qualify for the study will enroll in the intervention group and be treated using intratracheal epinephrine, and the second patient to qualify will enroll in the control group and be treated using intratracheal normal saline. That is, randomization is done by marking the even and odd numbers assigned to each case and is not considered as a sequential (non-random) style. This process will continue until the groups are completed, Blinding description: Patients are unaware of the type of intervention. 3 COVID-19. Intervention 1: Intervention group: Patients with severe COVID-19 under mechanical ventilation who receive intratracheal epinephrine. At the beginning of enrollment of patients in this group, for each patient in this group, 3 ml of adrenaline one in 1000 (manufactured by Iran Hormone Pharmaceutical Company) plus 2 ml of normal saline 0.9% (manufactured by Shahid Ghazi Pharmaceutical Company) is prescribed in a nebulized form. And the consequences mentioned in the presented plan are measured in the relevant schedule. Intervention 2: Control group: Patients with severe Covid-19 who receive intratracheal normal saline. Yes - There is a plan to make this available What will be shared: paper publication When: next one years To whom: all researchers Conditions: research use Where to obtain: Taraneh Naghibi How to obtain: By sending an email Comments:
public Taraneh Naghibi
Ayatollah Mousavi Hospital, Gavazang Road, Zanjan, Iran
Zanjan Iran (Islamic Republic of) 4513956183 +98 24 3342 0651 tnaghibi@zums.ac.ir Zanjan University of Medical Sciences scientific Taraneh Naghibi
Ayatollah Mousavi Hospital, Gavazang Road, Zanjan, Iran
Zanjan Iran (Islamic Republic of) 4513956183 +98 24 3342 0651 tnaghibi@zums.ac.ir Zanjan University of Medical Sciences Iran (Islamic Republic of) PCR positive for COVID-19 Tachypnea, cough and fever at the time of admission Under aggressive mechanical ventilation Pulmonary involvement in lung imaging 18 years no limit Both History of cardiovascular diseases History of brain diseases History of pulmonary diseases Pregnancy J12.81 Pneumonia due to SARS-associated coronavirus Treatment - Drugs Treatment - Drugs Intervention group: Patients with severe COVID-19 under mechanical ventilation who receive intratracheal epinephrine. At the beginning of enrollment of patients in this group, for each patient in this group, 3 ml of adrenaline one in 1000 (manufactured by Iran Hormone Pharmaceutical Company) plus 2 ml of normal saline 0.9% (manufactured by Shahid Ghazi Pharmaceutical Company) is prescribed in a nebulized form. And the consequences mentioned in the presented plan are measured in the relevant schedule. Control group: Patients with severe Covid-19 who receive intratracheal normal saline. Oxygen saturation. Timepoint: Oxygen saturation is measured before intervention and 5, 10, 30 and 60 minutes after intervention. Method of measurement: Using pulse oximetry and ABG. Zanjan University of Medical Sciences Approved 2021-10-27 Ethics committee of Zanjan University of Medical Sciences Zanjan University of Medical Sciences, Dr.Sobouti Blvd., Zanjan,Iran Zanjan Zanjan Iran (Islamic Republic of)