IRCT20210124050130N1 IRCT 2021-08-07 Islamic Azad University evaluation of the effect of duloxetine in reducing pain Evaluation of the Perioperative and Postoperative effects of Duloxetine in reducing postoperative pain in patients with spinal stenosis 2021-06-26 anticipated 64 Complete https://irct.ir/trial/56883 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients are randomly divided into two groups by simple randomization method. How to select people and place them in dual groups will be random. Thus, after confirming the necessary conditions to enter the study, patients will be selected sequentially, the first patient in the first group, the second patient in the second group. In the same way, again, the groups will take each patient until the desired limit is reached, the number of samples in the intervention and control groups is equal, Blinding description: The studied drugs were prepared by a neurosurgeon who did not participate in the project later and were stored in sealed envelopes on which the patient code was written. The envelopes were in the neurosurgery ward one day before surgery; Day of surgery; day after surgery; It is opened by a neurosurgeon who does not know the type of drug and the group in which the patient is placed. Nurses and patients are also unaware of the type of drug and the patient group. N/A Evaluation of the Perioperative and Postoperative effects of Duloxetine in reducing postoperative pain in patients with spinal stenosis. Intervention 1: Intervention group: will receive 60 mg of oral duloxetine daily for 1 day before surgery, 60 mg daily from the day of surgery to the first day after surgery (total 3 days). Intervention 2: Control group: placebo one day before surgery;day of surgery;one day after surgery. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is there is no more information