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IRCT20210428051118N1 IRCT 2021-08-06 University of social welfare and rehabilitation sciences Efficacy of vitamin B complex add-on therapy on positive, negative and cognitive symptoms of chronic schizophrenia Comparison of the effectiveness of vitamin B complex and placebo as adjunctive therapy on positive, negative and cognitive symptoms in patients with chronic schizophrenia; A double-blind randomized clinical trial. 2021-06-18 anticipated 50 Complete https://irct.ir/trial/56887 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Http://www.Randomization.com software was used to randomly divide people into two groups, Blinding description: Capsules of the same shape were used for this purpose. 3 Schizophrenia. Intervention 1: Control group: One placebo capsule daily (purchased from Poursina Pharmaceutical Company) , which is similar to the main drug in color, smell and taste, is added to their treatment regimen for three months. Intervention 2: Intervention group: One Bcomplex vitamin capsule daily (purchased from Poursina Pharmaceutical Company) is added to their treatment regimen for three months. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information.
public Somayeh Aqmasheh
Narmak
Tehran Iran (Islamic Republic of) 1649739834 +98 21 7709 2854 aqmasheh@gmqil.com University of social welfare and rehabilitation sciences scientific Somayeh Aqmasheh
Narmak
Tehran Iran (Islamic Republic of) 1649739834 +98 21 7709 2854 aqmasheh@gmqil.com University of social welfare and rehabilitation sciences Iran (Islamic Republic of) Suffering from Schizophrenia Do not have any other psychiatric disorder other than schizophrenia, for which a structured interview by a psychiatrist and the patient's test results are used Patients receiving atypical antipsychotic drug Having IQ in the normal range by measuring IQ by Raven test Obtain informed consent from the patient or his / her guardian no limit no limit Both Having any physically debilitating disease, whether prominent neurological or organic, including severe kidney and liver disease, for which a clinical examination by a physician and the patient's test results are used. Misuse of drugs or medications in the last six months Receive ECT in the last two weeks Patients who are contraindicated in vitamin B complex consumption F20 Schizophrenia Treatment - Drugs Treatment - Drugs Control group: One placebo capsule daily (purchased from Poursina Pharmaceutical Company) , which is similar to the main drug in color, smell and taste, is added to their treatment regimen for three months. Intervention group: One Bcomplex vitamin capsule daily (purchased from Poursina Pharmaceutical Company) is added to their treatment regimen for three months. Loosening of association. Timepoint: When entering the study, the end of the fourth, eighth and twelfth week. Method of measurement: PANSS (Positive And Negative Syndrome Scale). Delirium. Timepoint: When entering the study, the end of the fourth, eighth and twelfth week. Method of measurement: PANSS (Positive And Negative Syndrome Scale). Delusion. Timepoint: When entering the study, the end of the fourth, eighth and twelfth week. Method of measurement: PANSS (Positive And Negative Syndrome Scale). Strange behavior. Timepoint: When entering the study, the end of the fourth, eighth and twelfth week. Method of measurement: PANSS (Positive And Negative Syndrome Scale). Disorganized speech. Timepoint: When entering the study, the end of the fourth, eighth and twelfth week. Method of measurement: PANSS (Positive And Negative Syndrome Scale). Flat or blunted affect. Timepoint: When entering the study, the end of the fourth, eighth and twelfth week. Method of measurement: PANSS (Positive And Negative Syndrome Scale)،Calgary Depression Scale for Schizophrenia. Poverty of speech or poverty of content of speech. Timepoint: When entering the study, the end of the fourth, eighth and twelfth week. Method of measurement: PANSS (Positive And Negative Syndrome Scale)،Calgary Depression Scale for Schizophrenia. Thought blocking. Timepoint: When entering the study, the end of the fourth, eighth and twelfth week. Method of measurement: PANSS (Positive And Negative Syndrome Scale)،Calgary Depression Scale for Schizophrenia. Inappropriate makeup and appearance. Timepoint: When entering the study, the end of the fourth, eighth and twelfth week. Method of measurement: PANSS (Positive And Negative Syndrome Scale)،Calgary Depression Scale for Schizophrenia. Avolition. Timepoint: When entering the study, the end of the fourth, eighth and twelfth week. Method of measurement: PANSS (Positive And Negative Syndrome Scale)،Calgary Depression Scale for Schizophrenia. Anhedonia. Timepoint: When entering the study, the end of the fourth, eighth and twelfth week. Method of measurement: PANSS (Positive And Negative Syndrome Scale)،Calgary Depression Scale for Schizophrenia. Social withdrawal. Timepoint: When entering the study, the end of the fourth, eighth and twelfth week. Method of measurement: PANSS (Positive And Negative Syndrome Scale)،Calgary Depression Scale for Schizophrenia. Working memory problems. Timepoint: When entering the study, the end of the fourth, eighth and twelfth week. Method of measurement: Raven IQ Test،Montral Cognitive Assessment:MoCA. Cognitive impairment. Timepoint: When entering the study, the end of the fourth, eighth and twelfth week. Method of measurement: Raven IQ Test،Montral Cognitive Assessment:MoCA. Attention deficit. Timepoint: When entering the study, the end of the fourth, eighth and twelfth week. Method of measurement: Raven IQ Test،Montral Cognitive Assessment:MoCA. Tehran University of Social and Rehabilitation Sciences Approved 2021-06-13 Ethics Committee of University of Rehabilitation and Social Sciences University of Social Welfare and Rehabilitation Sciences, Koodkiar St., Daneshjoo Blvd., Velenjak Tehran Tehran Iran (Islamic Republic of)