IRCT20120215009014N399 IRCT 2021-06-21 Hamedan University of Medical Sciences Effect of hydroquinone 4% topical cream versus glucosamine 2% topical cream on treatment of melasma Effect of hydroquinone 4% topical cream versus glucosamine 2% topical cream on treatment of melasma: a double-blind randomized clinical trial 2021-07-06 anticipated 24 Complete https://irct.ir/trial/56953 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Random assignment of the right and left sides of the patients to the intervention and control groups through the drawing of lots. To do this, we prepare two sheets and write "right" on one sheet and "left" on another. Then, by referring to every patient, one of the sheets will be randomly taken. According to whether the sheet is taken right or left is assigned to the intervention group and the other side to the control group, Blinding description: The shape of the medications will be perfectly the same. Therefore, patients will be unaware of the type of intervention. The physician who will examine the patients will not be aware of the intervention. Thus, the trial will be run as double -blind. 3 Melasma. Intervention 1: Intervention group 1: Hydroquinone 4% topical cream (manufactured by Behvarzan Pharmaceutical Co.) once every night for 8 weeks plus SFP50 sunscreen (manufactured by Dr. Jila Pharmaceutical Co.) 3 times a day for 8 weeks. Intervention 2: Intervention group 2:Glucosamine 2% topical cream (manufactured by Behvarzan Pharmaceutical Co.) once every night for 8 weeks plus SFP50 sunscreen (manufactured by Dr. Jila Pharmaceutical Co.) 3 times a day for 8 weeks. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is It depends on the situation and the results of the study as well as the approval of the financial supporting organization.