IRCT20210619051619N1 IRCT 2021-10-29 Royan Institute N-acetyl cysteine and endometrioma Effect of N-acetyl cysteine on oxidative stress biochemical factors and IVF/ICSI outcomes in women with endometrioma: A randomized, double-blinded, phase III Clinical Trial 2021-04-13 anticipated 140 Complete https://irct.ir/trial/56973 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: The permuted blocks is method for random allocation. The size of the blocks varies, including 10 blocks and 4 blocks. The allocation ratio is equal in both groups. As soon as the included patient a unique identification code is assigned to the patient and will not change during the study, Blinding description: Participants, principle investigator, and healthcare providers do not have information about two study groups. 3 Endometrioma. Intervention 1: Intervention group: Participants who randomly assigned in the intervention group, during 6 weeks simultaneous to start standard long agonist protocol or antagonist induction, will be received 1200 (2×600) mg of effervescent tablets of NAC daily. Blood will collect before the intervention and at the time of oocyte retrieval (end of 6 week), in addition to, follicular fluid will be obtained from the mature follicles. Also, we will measure severity of dysmenorea by visual analogue scale (VAS) technique. Intervention 2: Control group: Participants who randomly assigned to the control group, during 6 weeks simultaneous to start the standard long agonist protocol, or antagonist induction, will be received 1200 (2×600) mg of placebo tablets of NAC daily. Blood will collect before the intervention and at the time of oocyte retrieval, in addition to, follicular fluid will be obtained from the mature follicles. Also, we measure severity of dysmenorrhea by visual analogue scale (VAS) technique. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information