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IRCT20210621051642N1 IRCT 2021-07-05 Sabzevar University of Medical Sciences Evaluation of therapeutic effect of Simospan syrup on covid-19 Evaluation of therapeutic effect of Simospan syrup (contains of Thymus vulgaris, Hedera helix, Honey and Vitamin C) on duration of hospitalization in covid-19 patients 2021-06-26 anticipated 52 Complete https://irct.ir/trial/56998 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Randomization will be done based on the table of random numbers using Excel software and with the Randbetween command between 52 samples. The control group(A) does not receive any treatment over common treatment.The 26 numbers of intervention group(B) receives the simospan syrup,. Patients numbers from 000-026 and 027-052 are considered for groups A and B respectively, Blinding description: Analyzer and data collecting man not be aware of intervention type and participants in control and intervention groups.so the trial will be run as single-blind. 2-3 covid-19. Intervention 1: Control group: routine treatment based on physician's order. Intervention 2: Intervention group: routine treatment based on physician's order and simospan syrup (every 8 hours 6 cc for 5 days). Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is I have not yet decided.its release program is not clear.
public Sajad Seyedi
Heshmatieh hospital, Asadabadi street
Sabzevar Iran (Islamic Republic of) 9613873140 +98 51 4401 1954 sajadseyedi2004@gmail.com Sabzevar University of Medical Sciences scientific Sajad Seyedi
Heshmatie hospital, Asadabadi street
Sabzevar Iran (Islamic Republic of) 9613873140 +98 51 4401 1954 sajadseyedi2004@gmail.com Sabzevar University of Medical Sciences Iran (Islamic Republic of) Age limitation (30-60 years old) Hospitalized patients with CT-scan findings in favor of Covid-19 disease Hospitalized patients with the amount of blood oxygen saturation below 93% Hospitalized patients with Chest X-ray findings in favor of pneumonia Hospitalized patients without underlying disease 30 years 60 years Both Pregnancy and lactation End-stage Covid-19 patients Patients diagnosed with underlying disease and organ damage U07.1 COVID-19, virus identified Treatment - Other Treatment - Drugs Control group: routine treatment based on physician's order Intervention group: routine treatment based on physician's order and simospan syrup (every 8 hours 6 cc for 5 days) The spent time to illness improvement. Timepoint: Before and 5 days after the start of intervention. Method of measurement: Variable type is qualitative and its scale is nominal.the criterion of recovery records and descripts based on observations of data collecting man in checklist.relative criterion based on clinical symptoms:1-non-admission along with the return of normal activity-2-non-admission along without the return of normal activity-3-admission without the need for oxygentherapy-4-admission with the need for oxygentherapy-5-admission with the need to receive high speed oxygen from the nose or non invasive ventilation or both-6-admission with the need to receive oxygen therapy with invasive ventilation or oxygen therapy from non pulmonary pathways or both-7- patient's death. Discharge from hospital. Timepoint: After the start of intervention. Method of measurement: Duration of hospitalization. The blood level of ALT enzyme. Timepoint: Before and 5 days after the start of intervention. Method of measurement: Spectrometer. The blood level of BUN. Timepoint: Before and 5 days after the start of intervention. Method of measurement: Spectrometer. The blood level of creatinine. Timepoint: Before and 5 days after the start of intervention. Method of measurement: Spectrometer. The blood level of AST enzyme. Timepoint: Before and 5 days after the start of intervention. Method of measurement: Spectrometer. RBC count. Timepoint: Before and 5 days after the start of intervention. Method of measurement: Cell counter. WBC count. Timepoint: Before and 5 days after the start of intervention. Method of measurement: Cell counter. The blood level of HG. Timepoint: Before and 5 days after the start of intervention. Method of measurement: Auto analyzer machine. The blood level of HCT. Timepoint: Before and 5 days after the start of intervention. Method of measurement: Auto analyzer machine. CRP blood test. Timepoint: Before and 5 days after the start of intervention. Method of measurement: ELISA kits. ESR test. Timepoint: Before and 5 days after the start of intervention. Method of measurement: Wintrobe method. Sabzevar University of Medical Sciences Approved 2021-06-20 Ethics committee of Sabzevar University of Medical Sciences Nuclear martyrs boulevard-Above the memorial of the anonymous martyrs-sabzevar university of med-sci pardis Sabzevar Razavi Khorasan Iran (Islamic Republic of)