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IRCT20210620051629N1 IRCT 2021-08-18 Shiraz University of Medical Sciences The assessment of curcumin in comparison with placebo on the auditory neuropathy in chronic kidney disease and diabetes mellitus patients The assessment of curcumin in comparison with placebo on the auditory neuropathy in chronic kidney disease and diabetes mellitus patients 2021-08-23 anticipated 40 Complete https://irct.ir/trial/57004 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: The method of permutation bloc randomization with quadri-bloces, Blinding description: In this study, the investigator and the participant are not aware of the drug. Each patient in the experimental group receives a 500 mg capsule of curcumin daily for 8 weeks, and in the control group, each patient receives starch-containing capsules for 8 weeks. Each patient receives the medication in pre-packaged bottles. All placebo drugs and tablets are the same color, weight, shape, and size. 3 Chronic kidney disease. Intervention 1: Intervention group: Daily consumption of one capsule of 500 mg of turmeric extract (containing 475 mg of curcuminoid, Karen Company) for 8 weeks. Intervention 2: Control group: Daily consumption of one starch capsule for 8 weeks. Yes - There is a plan to make this available What will be shared: Part of the data can be shared after unidentified When: 6 months after publication To whom: Interested researchers in this field Conditions: Using for research works Where to obtain: Research and technology deputy How to obtain: Sending an Email to research and technology deputy. Comments:
public Aida Doostkam
ZAND Ave, Shiraz University of Medical Sciences
Shiraz Iran (Islamic Republic of) 71348-14336 +98 71 3235 7282 doostkam@sums.ac.ir Shiraz University of Medical Sciences scientific Aida Doostkam
ZAND Ave, Shiraz University of Medical Sciences
Shiraz Iran (Islamic Republic of) 71348-14336 +98 71 3235 7282 doostkam@sums.ac.ir Shiraz University of Medical Sciences Iran (Islamic Republic of) All chronic kidney and diabetic patients with definitive diagnosis of nephrologist and endocrinologist who have been ill for more than 6 months All patients with chronic renal disease and diabetes with definitive diagnosis who have hearing impairment in the initial evaluation All chronic renal and diabetic patients with definitive diagnosis with glomerular filtration rate less than 60 18 years 50 years Both Use of aspirin and warfarin Mental diseases Usage of other complementary medicine methods Pregnancy lactation Usage of other antioxidant drugs except Nephrovit pills Having gallstones N18 Chronic kidney disease (CKD) Treatment - Drugs Placebo Intervention group: Daily consumption of one capsule of 500 mg of turmeric extract (containing 475 mg of curcuminoid, Karen Company) for 8 weeks Control group: Daily consumption of one starch capsule for 8 weeks Hearing threshold based on auditory brain stem responses (ABR). Timepoint: Before intervention, After intervention. Method of measurement: Minimum hearing threshold based on auditory brain stem responses (ABR). Shiraz University of Medical Sciences Approved 2021-07-11 Ethics committee of Shiraz University of Medical Sciences ZAND street, Shiraz University of Medical Sciences Shiraz Fars Iran (Islamic Republic of)