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IRCT20190831044650N3 IRCT 2021-08-22 Sari branch, Islamic Azad University The effect of high intensity interval resistance training and vitamin D intake onvitamin D th and anti inflammatory-oxidative status in overweight women The effect of high intensity interval resistance training and vitamin D intake on the levels of Sirtuin1, Eotaxin-1 and some anti inflammatory-oxidative markers in overweight women with low vitamin D status. 2021-08-21 anticipated 78 Complete https://irct.ir/trial/57005 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Used, Assignment: Parallel, Purpose: Supportive, Randomization description: At first, the subjects will be selected using a simple random method. Then, using a table of random numbers, they are divided into six groups: control, resistance interval, running interval, vitamin D, resistance interval+vitamin D and running interval+ vitamin D. Therefore, each of the candidates will be assigned a two-digit number from 01, 02, …, 10, 11, …, to 52. The same number of digits is determined for the selection of individuals by starting a hand movement from a point in the table of random numbers in the direction of the desired row or column (five-digit numbers whose last two digits are similar to the existing codes) and each is randomly assigned to One of the groups. This will continue until the number of people in each group is completed. Therefore, the researcher will not have the option to change the status of the assignment or predict it. Random disguise will be done by a third party who does not participate in other stages of the intervention, Blinding description: Analysts will be blind. The researcher will administer vitamin D capsules (50,000 units) to vitamin D, resistance interval+ vitamin D, running interval+ vitamin D individuals as well as placebo to control and exercise groups. N/A Condition 1: Overweight. Condition 2: Vitamin D deficiency. Intervention 1: Control group: There is no intervention in the control group and they are given placebo in a single blind manner. Intervention 2: Intervention group 1: Vitamin D group, who take 50,000 IU of vitamin D capsules once a week for 8 weeks. Intervention 3: Intervention group 2: resistance interval group will perform 8 weeks and three times a week of high intensity interval resistance training consisting of three sets of 6 repetitions at 70% of 1repetition maximum (RM) and then 20 seconds of rest between repetitions until exhaustion repeated for 3 times with 2 .30” rest between sets. They will also take a placebo capsule containing oral paraffin weekly. Intervention 4: Intervention group 3: Subjects in this group will have 8 weeks of high intensity interval resistance training similar to the interval resistance group and will consume 50,000 IU of vitamin D capsules once a week. Intervention 5: Intervention group 3: running interval group will perform 8 weeks and three times a week of high intensity interval running training consisting of 12 x 1-min running bouts at 80-90% HRmax interspersed with 1-min active recovery at 50%HRmax. They will also take a placebo capsule containing oral paraffin weekly. Intervention 6: Intervention group 5: Subjects in this group will have 8 weeks of high intensity interval running training similar to the interval running group and will consume 50,000 IU of vitamin D capsules once a week. No - There is not a plan to make this available Justification or reason for not sharing IPD is No more information
public Masoumeh habibian
7km Allameh Tabarasi street, Qaemshahr Branch, Islamic Azad University, Qaemshahr
Qaemshahr Iran (Islamic Republic of) 4765161964 +98 11 4224 1041 habibian_m@yahoo.com Qaemshahr branch, Islamic Azad University scientific Masoumeh Habibian
7 kilometers from Allameh Tabari Street, Islamic Azad University of Ghaemshahr Branch, Ghaemshahr, Iran.
Ghaemshahr Iran (Islamic Republic of) 4765161964 +98 11 4224 1041 habibian_m@yahoo.com Qaemshahr branch, Islamic Azad University Iran (Islamic Republic of) Having a body mass index between 25 to 29 kg / m2 Not participating in regular sports activities for the past six months Not having cardiovascular disease Not having hypertension Not having Inflammatory diseases Serum levels of 25-hydroxyvitamin D less than 30 ng / ml 23 years 29 years Female Use any specific medications or supplements Pregnancy Smoking E66.0 E50.5 Obesity due to excess calories Vitamin D deficiency Placebo Treatment - Other Treatment - Other Treatment - Other Treatment - Other Treatment - Other Control group: There is no intervention in the control group and they are given placebo in a single blind manner Intervention group 1: Vitamin D group, who take 50,000 IU of vitamin D capsules once a week for 8 weeks. Intervention group 2: resistance interval group will perform 8 weeks and three times a week of high intensity interval resistance training consisting of three sets of 6 repetitions at 70% of 1repetition maximum (RM) and then 20 seconds of rest between repetitions until exhaustion repeated for 3 times with 2 .30” rest between sets. They will also take a placebo capsule containing oral paraffin weekly Intervention group 3: Subjects in this group will have 8 weeks of high intensity interval resistance training similar to the interval resistance group and will consume 50,000 IU of vitamin D capsules once a week. Intervention group 3: running interval group will perform 8 weeks and three times a week of high intensity interval running training consisting of 12 x 1-min running bouts at 80-90% HRmax interspersed with 1-min active recovery at 50%HRmax. They will also take a placebo capsule containing oral paraffin weekly. Intervention group 5: Subjects in this group will have 8 weeks of high intensity interval running training similar to the interval running group and will consume 50,000 IU of vitamin D capsules once a week. Eotaxin-1. Timepoint: Before the intervention and 8 weeks after the intervention. Method of measurement: Using the ELISA method. Sirtuin1. Timepoint: Before the intervention and 8 weeks after the intervention. Method of measurement: Using the ELISA method. Interlukin10. Timepoint: Before the intervention and 8 weeks after the intervention. Method of measurement: Using the ELISA method. 25- hydroxy vitamin D. Timepoint: Before and after interventions. Method of measurement: Using the ELISA method. Brain-Derived Neurotrophic Factor. Timepoint: Before the intervention and 8 weeks after the intervention. Method of measurement: Using the ELISA method. Superoxide dismutase. Timepoint: Before the intervention and 8 weeks after the intervention. Method of measurement: Laboratory methods. Tumor necrosis factor alpha. Timepoint: Before the intervention and 8 weeks after the intervention. Method of measurement: Using the ELISA method. Monocyte Chemoattractant Protein 1. Timepoint: Before the intervention and 8 weeks after the intervention. Method of measurement: Using the ELISA method. Malondialdehyde. Timepoint: Before the intervention and 8 weeks after the intervention. Method of measurement: spectrophotometrically. Homocysteine. Timepoint: Before the intervention and 8 weeks after the intervention. Method of measurement: Using the ELISA method. Total Antioxidant Capacity. Timepoint: Before the intervention and 8 weeks after the intervention. Method of measurement: Ferric Reducing/Antioxidant Power. Transforming growth factor-beta 1 (TGF-beta1). Timepoint: Before the intervention and 8 weeks after the intervention. Method of measurement: Using the ELISA method. Vascular endothelial growth factor (VEGF). Timepoint: Before the intervention and 8 weeks after the intervention. Method of measurement: Using the ELISA method. C-Reactive Protein (CRP). Timepoint: Before the intervention and 8 weeks after the intervention. Method of measurement: Using the ELISA method. Adiponectin. Timepoint: Before the intervention and 8 weeks after the intervention. Method of measurement: Using the ELISA method. Thyroid stimulating hormone. Timepoint: Before the intervention and 8 weeks after the intervention. Method of measurement: Using the ELISA method. Sleep quality. Timepoint: Before and after interventions. Method of measurement: Sleep quality questionnaire. Quality of Life. Timepoint: Before the intervention and 2 weeks after the intervention. Method of measurement: Quality of Life Questionnaire. Sari branch, Islamic Azad University Approved 2021-04-27 Ethics Committee of Sari branch, Islamic Azad University 7 km Darya Road, Sari, Islamic Azad University, Sari Branch, Iran Sari Mazandaran Iran (Islamic Republic of)