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IRCT20160308026971N12 IRCT 2021-07-30 Rafsanjan University of Medical Sciences Investigating the effect of Nettle and Alyssum with Q10 plus and L-Carnitine on improving sperm parameters of infertile men Comparison of the effect of Nettle and Alyssum with Q10 plus and L-Carnitine on improving sperm parameters of infertile men referred to infertility clinic 2021-07-23 anticipated 70 Complete https://irct.ir/trial/57039 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: In this study, we use a random number table to assign infertile men to the control and intervention groups. The table of random numbers consists of random digits 0 to 9 And each of the digits in this table is repeated the same on average And there is no pattern of recognizable numbers. We make a random list using the random digits in the table, assigning each digit to a therapeutic appointment. Now for the two treatments, we assign the numbers 4-0 for treatment A and the numbers 5-9 for treatment B. We start the list at an optional point in the table that we have chosen at random. For example, if we start from the top row of the random number table randomly and optionally and And from left to right of the table and then move to the bottom rows, they create a list Which begins with the following treatments. We will continue to do this until our sample is complete, Blinding description: The meaning of the three blinds is that the participants (people qualified to enter the project)، Assessor (the person who is to complete the relevant checklist before and 12 weeks after treatment) And Data Analyzer (Statistics Specialist) Unaware of which group (intervention or control) the information received and statistical data belong to. 3 Male Infertility. Intervention 1: Intervention group: Intervention group: Taking orthidine tablets (nettle) 150 mg, Made by Barij Essence Pharmaceutical Company 3 daily (7 am, 13 and 19 pm) and aqueous extract of Qadoomeh, 2 capsules of 300 mg daily (9 am and 9 pm) Which will be made by the Faculty of Pharmacy of Kerman University of Medical Sciences، For 12 weeks. Intervention 2: Control group: Control group: Qu10 Plus 100 mg tablets daily (9 am) Made by the German pharmaceutical company Eurovital and L-carnitine 500 mg tablets daily (9 pm) Made by Karen Iran Pharmaceutical Company For 12 weeks. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is not more information
public Marzeyeh loripoor
Faculty of Nursing and Midwifery, Nursing street
Rafsanjan Iran (Islamic Republic of) 7718796755 +98 34 3428 0035 marzeyehloripoor@yahoo.com Rafsanjan University of Medical Sciences scientific Marzeyeh loripoor
Faculty of Nursing and Midwifery, Nursing street
Rafsanjan Iran (Islamic Republic of) 7718796755 +98 34 3428 0035 marzeyehloripoor@yahoo.com Rafsanjan University of Medical Sciences Iran (Islamic Republic of) Willingness to participate in the study and written consent Living with a spouse Iranian nationality Age 20 to 45 years Disorder in at least one of the sperm parameters (At least 20 million sperm per milliliter of semen, 50% progressive motion And 4% of normal morphology) Infertility after 12 months of intercourse without using contraceptive methods 20 years 45 years Male Spouse infertility Autoimmune diseases and chronic diseases that are known to affect fertility, such as cardiovascular disease, diabetes, hypertension Alcohol, cigarette and drug addiction Mental illness Severe marital conflicts History of radiation therapy and various cancers History of previous or current genitourinary tract diseases such as varicocele N46 Male infertility Treatment - Drugs Treatment - Drugs Intervention group: Intervention group: Taking orthidine tablets (nettle) 150 mg, Made by Barij Essence Pharmaceutical Company 3 daily (7 am, 13 and 19 pm) and aqueous extract of Qadoomeh, 2 capsules of 300 mg daily (9 am and 9 pm) Which will be made by the Faculty of Pharmacy of Kerman University of Medical Sciences، For 12 weeks Control group: Control group: Qu10 Plus 100 mg tablets daily (9 am) Made by the German pharmaceutical company Eurovital and L-carnitine 500 mg tablets daily (9 pm) Made by Karen Iran Pharmaceutical Company For 12 weeks Sperm parameters in infertile men. Timepoint: Before the intervention and 12 weeks after the start of the intervention. Method of measurement: The checklist consists of two parts: the first part is the demographic characteristics and the second part is the spermogram parameters. Number of sperm. Timepoint: Before the intervention and 12 weeks after the start of the intervention. Method of measurement: The checklist consists of two parts: the first part is the demographic characteristics and the second part is the spermogram parameters. Sperm motility. Timepoint: Before the intervention and 12 weeks after the start of the intervention. Method of measurement: The checklist consists of two parts: the first part is the demographic characteristics and the second part is the spermogram parameters. Sperm morphology. Timepoint: Before the intervention and 12 weeks after the start of the intervention. Method of measurement: The checklist consists of two parts: the first part is the demographic characteristics and the second part is the spermogram parameters. Rafsanjan University of Medical Sciences Approved 2021-06-26 Ethics Committee of Rafsanjan University of Medical Sciences No. 33, Alley 41, Mostafa Khomeini St Rafsanjan Kerman Iran (Islamic Republic of)