IRCT20170805035510N7 IRCT 2022-01-20 Tehran University of Medical Sciences Comparison of the effect of mannitol and hypertonic sodium administration to reduce ICP on hemodynamic parameters Comparison of the effect of mannitol and hypertonic sodium administration to reduce ICP on hemodynamic parameters under LiDCO monitoring in patients undergoing elective craniotomy 2022-02-20 anticipated 22 Complete https://irct.ir/trial/57298 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Using the website www.sealedenvelope.com/, quadruple blocks were generated for randomization. The number of generated blocks will be 12 (sample size 44). The website generates blocks randomly (taking into account the number of study groups They are equal in each block) then they are provided to the person as Excel output. The determination of entry to the study is done based on the blocks made in order to intervention or control groups based on generated blocks. 4 Craniotomy. Intervention 1: Intervention group: Receive 5 ml / kg mannitol 20% by slow intravenous injection after induction of anesthesia. Intervention 2: Intervention group: Receive 3 mg / kg of hypertonic serum 5.% by slow intravenous injection after induction of anesthesia. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is "There is no more information."