]>
IRCT20170510033909N12 IRCT 2021-07-14 Islamic Azad University, Isfahan Branch (Khorasgan), Research Deputy Exercise and migraine The effect of combined combination of Mg, B12 and intense aerobic exercise on CGRP in women with migraine 2021-07-23 anticipated 60 Complete https://irct.ir/trial/57317 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Supportive, Randomization description: Randomization method: Simple randomization; Randomization Tool: Random Number Table; Randomization Unit: Individual; In order to use a table of random numbers, the researcher will first determine the reading position of the table numbers. The numbers will then be considered for different groups. For example, zero to twenty-four for intervention A, twenty-five to forty-nine for intervention B, fifty to seventy-four for group C, and seventy-five to nine for group D. Then we will touch one of the numbers and move in one of the predetermined directions. The numbers will be recorded and assigned to four groups: aerobic exercise, Mg intake, B12, combination and control. In order to hide random allocation, the method of coded boxes with random sequence will be used. This method uses a number of boxes that are numbered randomly. Adequate sealing of the boxes, their apparent similarity and their weight will be ensured. N/A migraine. Intervention 1: Intervention group 1 : Intense aerobic exercise:The training program consists of three parts: warm-up, main stage and cooling. The warm-up and cooling phase includes 10 minutes and the main phase of training with the Astrand bike with 60% of the maximum heart rate in the first week and 85% of the maximum heart rate in the eighth week. Intervention 2: Intervention group 2 : One tablet of 250 mg of magnesium and 1 mg of B12 daily for 8 weeks. Intervention 3: Intervention group 3 : Supplementation and aerobic exercise:Exercise program includes exercise with Astrand bike with 60% of maximum heart rate in the first week and 85% of maximum heart rate in the eighth week. Take one 250 mg magnesium and 1 mg B12 tablet daily for 8 weeks. Intervention 4: Control group: No intervention, only follow up. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is No more information
public Farzaneh taghian
Khorasgan University, Arghavanie St, Isfahan
Isfahan Iran (Islamic Republic of) 8183895183 +98 31335002352 F_taghian@yahoo.com Islamic Azad University scientific Islamic Azad University
Khorasgan University, Arghavanie St, Isfahan
Isfahan Iran (Islamic Republic of) 8183895153 +98 81 8389 5183 F_taghian@yahoo.com Farzaneh Taghian Iran (Islamic Republic of) Confirmation of migraine by a doctor 20 years 50 years Female Do not take food supplements in the last 3 months Lack of sports history in the last 6 months G43 Migraine Rehabilitation Lifestyle Lifestyle N/A Intervention group 1 : Intense aerobic exercise:The training program consists of three parts: warm-up, main stage and cooling. The warm-up and cooling phase includes 10 minutes and the main phase of training with the Astrand bike with 60% of the maximum heart rate in the first week and 85% of the maximum heart rate in the eighth week. Intervention group 2 : One tablet of 250 mg of magnesium and 1 mg of B12 daily for 8 weeks Intervention group 3 : Supplementation and aerobic exercise:Exercise program includes exercise with Astrand bike with 60% of maximum heart rate in the first week and 85% of maximum heart rate in the eighth week. Take one 250 mg magnesium and 1 mg B12 tablet daily for 8 weeks. Control group: No intervention, only follow up Calcitonin Gene-Related Peptide. Timepoint: At the beginning and end of 8 weeks of study. Method of measurement: Serum concentration of CGRP by ELISA method using the Eastbiopharm Monobind CHINA. Islamic Azad University, Isfahan Branch (Khorasgan), Research Deputy Approved 2021-06-02 Ethics Committee on Research Islamic Azad University - Isfahan Branch (Khorasgan) University Blvd, Arghavanie, East Gay Street, Isfahan Isfahan Isfehan Iran (Islamic Republic of)