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IRCT20210707051809N1 IRCT 2022-07-18 Babol University of Medical Sciences The effect of acetazolamide on respiratory parameters of mechanically ventilated patients Evaluating the effect of adding acetazolamide to routine regimen on respiratory parameters of mechanically ventilated patients in the intensive care unit 2022-08-23 anticipated 30 Complete https://irct.ir/trial/57397 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Not used, Assignment: Other, Purpose: Treatment, Randomization description: The study samples will be randomly assigned to two intervention and control groups (blocked) using the two-way block method, which will be the intervention group (A) and the control group (B). AA, BB, BA, AB state will be created and these states will be written on separate cards, and the doctor will take out the patient card from the bag randomly for fifteen separate times and will write these states in order. For example, if the first card is AB, it means that the first patient is part of the intervention group and the second patient is in the control group, and sampling is done randomly until the states are finished, Blinding description: In this study, the patients and the clinical caregivers and the data analyzer are not aware of the study method. N/A Patients connected to a ventilator. Intervention 1: Intervention group: Patients connected to a ventilator who, in addition to routine care, take acetazolamide tablets. Acetazolamide 250 mg tablets are administered orally (gavage) twice daily for 3 consecutive days. Intervention 2: Control group: Patients connected to a ventilator who receive only routine care and do not take acetazolamide tablets. Yes - There is a plan to make this available What will be shared: After the end of the study and data analysis, the results and data, including the study protocol, statistical analysis map, clinical study report, after removing the confidential information, will be available to all people who want to access and use this study. When: 2023 To whom: Everyone Conditions: Access is free Where to obtain: behnam.esbakian@gmail.com How to obtain: Send email Comments:
public Behnam Esbakian Bandpey
Babol University of Medical Sciences; Ganj Afrooz Street
Babol Iran (Islamic Republic of) ۴۷۱۷۶-۴۷۷۴۵ +98 11 3219 9592 BEHNAM.ESBAKIAN@GMAIL.COM Babol University of Medical Sciences scientific Behnam Esbakian Bandpey
Babol University of Medical Sciences; Ganj Afrooz Street
Babol Iran (Islamic Republic of) ۴۷۱۷۶-۴۷۷۴۵ +98 11 3219 9592 BEHNAM.ESBAKIAN@GMAIL.COM Babol University of Medical Sciences Iran (Islamic Republic of) Patients should be connected to a ventilator Patients diagnosed with non-traumatic illness (absence of trauma, especially head and chest trauma) Age over 18 years old 18 years no limit Both Hemodynamic instability (patients during heart shock and severe cardiovascular disorders, patients with brain death, patients in need of pacemakers, patients with renal failure, etc.) Presence of metabolic acidosis in the ABG test Treatment - Drugs Treatment - Other Intervention group: Patients connected to a ventilator who, in addition to routine care, take acetazolamide tablets. Acetazolamide 250 mg tablets are administered orally (gavage) twice daily for 3 consecutive days. Control group: Patients connected to a ventilator who receive only routine care and do not take acetazolamide tablets Respiratory rate. Timepoint: Four times a day (morning, once before and once after) - (evening, once before and once after) and for 3 consecutive days. Method of measurement: Cardiopulmonary monitoring device and ventilator device. Tidal volume. Timepoint: Four times a day (morning, once before and once after) - (evening, once before and once after) and for 3 consecutive days. Method of measurement: Cardiopulmonary monitoring device and ventilator device. Percentage of hemoglobin saturated with oxygen. Timepoint: Four times a day (morning, once before and once after) - (evening, once before and once after) and for 3 consecutive days. Method of measurement: Cardiopulmonary monitoring device and ventilator device. Babol University of Medical Sciences Approved 2021-07-09 Ethics committee of Babol University of Medical Sciences Babol University of Medical Sciences; Ganj Afrooz Street Babol Mazandaran Iran (Islamic Republic of)