IRCT20170929036477N4 IRCT 2021-08-10 Shahre-kord University of Medical Sciences The effect of curcumin and vitamin D s on headache symptoms and inflammation in patients with migraine The effect of concurrent curcumin and vitamin D supplementation on headache symptoms and calcitonin gene-related peptide level (CGRP) in patients with migraine 2021-08-28 anticipated 60 Complete https://irct.ir/trial/57843 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Eligible subject be selected with convenience sampling and be randomly assigned into 2 groups of 25 subjects as treatment and control with block sizes of 3 and 6 with proportion 1:1. A person from research team not involved in the recruitment and assigning participants generate allocation sequence using web site of www.Randomization.com, Blinding description: After explaining the purpose of the study, all participants and investigators are blinded to random allocation. Participants in vitamin D group receive vitamin D 1000 IU supplement and curcumin capsules while control group take placebo with the same size and color as vitamin D(Oral paraffin) soft gels and curcumin. 3 Migraine. Intervention 1: "Intervention group": migraine patients intake curcumin supplement in the form of 500 mg capsules from Karen Company, one per day with routine treatment (200 mg sodium valproate tablets from Sajad Darou 2/day and two 20 mg propranolol tablets from Tolid Darou) and a soft oral vitamin D capsule with a dose of 2000 international units produce by Zahravi Company daily for 60 days. Intervention 2: "Control group": migraine patients intake placebo of curcumin and vitamin D supplement one per day with routine treatment (two 200 mg sodium valproate tablets and two 20 mg propranolol tablets) for 60 days. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information.