IRCT20130701013828N8 IRCT 2021-10-04 Islamic Azad University Protective effects of Bisoprolol against anthracycline-induced cardiomyopathy in breast cancer patient Protective effects of Bisoprolol against anthracycline-induced cardiomyopathyin in breast cancer patient 2021-10-23 anticipated 90 Complete https://irct.ir/trial/57932 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention, Randomization description: In this study use block randomization and unit of randomization is individual. Block randomization divides patients into M blocks of size 2N, so that in each block N patients are assigned A and patients N are assigned to B. The block is then selected randomly.The size of the block is not stated in the study so that researchers are blind to it.Rand Excel function randomization tool is helpful, Blinding description: Patients are treated with medication packages pre-determined by the study supervisor. Drug packages are exactly the same in shape and the patient and the project facilitator are not aware of the contents of the packages. The executor and his assistant are done who are not aware of the contents of the packages; In the data analysis stage, the analysis will be performed by the project consultant and the project manager who are not aware of the contents of the drug packages and only the group of patients (group 1 or 2) will be identified for data analysis; Therefore, the study is three-blind and the contents of the two drug groups are not clear from the stage of patient entry into the study to the study, data collection and analysis. 3 chemotherapy induced cardiomyopathy in breast cancer patients. Intervention 1: Intervention group: 2.5 mg Bisoprolol tablets from Abidi company are taken daily from one week before the start of chemotherapy until the end of the chemotherapy course. Intervention 2: Control group: Placebo is given to the control group like intervention group from one week before the start of chemotherapy until the end of the chemotherapy course. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information.