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IRCT20210516051323N1 IRCT 2021-11-16 Islamic Azad University Effect of Quercetin on PCOS patients Effect of quercetin on the inflammatory factors NfKb, TnfAlpha, Il6 and expression of the Nrf2 and Keap1 genes in poly cystic ovary syndrome (PCOS Patients) 2021-10-22 anticipated 42 Complete https://irct.ir/trial/57934 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: (Block Randomization) 42 patients are randomly assigned to the intervention and control groups by blocking method, and each for a period of 40 days from the beginning of the menstrual cycle to the day of ovulation, will receive a daily dose of 500 mg of quercetin for the intervention group or a placebo for the control group, Blinding description: Blinding is done by assigning a number to each patient. Quercetin and placebo capsules are the same. A person who is not involved in the study prepares the containers of both groups by placing quercetin and placebo tablets in the same containers and assigning codes. Both researchers and study participants are blind from the time of randomization to the time of data analysis. N/A Poly Cystic Ovary Syndrome. Intervention 1: For Intervention Group: quercetin, Orally 500 mg/day (1 Cap.) for 40 days from the beginning of the menstruation cycle till oocyte retrieval. Intervention 2: Intervention group: Placebo of quercetin, Orally 1 Cap. for 40 days from the beginning of the menstruation cycle till oocyte retrieval. Yes - There is a plan to make this available What will be shared: Part of the participants data related to main topic of research When: 6 months after first formal issue To whom: Academic Researchers Conditions: Written Approval Where to obtain: Sima Vaez How to obtain: Submit a request via email Comments:
public Sima Vaez
unit3 no53 pabarja st shariati st Tehran
Tehran Iran (Islamic Republic of) 1949635771 +98 21 4022 8954 vaezmrs@gmail.com Islamic Azad University scientific kazem parivar
Tehran,The end of Shahid Sattari Highway ,University Square of Shohada Hesarak Boulevard ,Islamic Azad University, Science and Research Branch
Tehran Iran (Islamic Republic of) 1477893855 +98 21 4486 5179 basic-fa@srbiau.ac.ir Islamic Azad University Iran (Islamic Republic of) Infertility with documented PCOS & Hyperandrogenism;20-37Y/O; Candidate for IVF Cycle; If have male factor; it must mild to moderate form, not non-obstructive azospermia; If have other female factor; only cervical & tubal factors are acceptable. 20 years 37 years Female Placebo Placebo For Intervention Group: quercetin, Orally 500 mg/day (1 Cap.) for 40 days from the beginning of the menstruation cycle till oocyte retrieval. Intervention group: Placebo of quercetin, Orally 1 Cap. for 40 days from the beginning of the menstruation cycle till oocyte retrieval. Inflamatory factors TNfAlpha, IL6. Timepoint: Before consumption and after puncture surgery. Method of measurement: Elaysa Test on blood sample. Effects on expression of Nrf2-Keap1 genes. Timepoint: After puncture surgery. Method of measurement: Real Time PCR Device records. Protein expression, Keap-1. Timepoint: After the intervention. Method of measurement: western blot. Islamic Azad University Approved 2021-02-14 Ethics committee of islamic azad university science and research branch Tehran Daneshgah Sq, North end sattari Exw, Tehran, Iran Tehran Tehran Iran (Islamic Republic of)