IRCT20210808052105N1 IRCT 2022-01-02 Tehran University of Medical Sciences Assess the efficacy of multitarget therapy in prevention of Avascular necrosis (AVN) A Randomized Controlled Trial (RCT) to assess the efficacy of multitarget therapy in prevention of avascular necrosis (AVN) in patients taking high dose steroid in two groups (case and control) 2022-02-18 anticipated 70 Complete https://irct.ir/trial/57991 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention, Randomization description: Balance Blocked Randomization method was used for randomization using Stata software. Random allocation is done using size 4 blocks. The total sample size of 70 patients is estimated, including lost to follow up, about 15% of 10 samples were added to the samples to observe the minimum study capacity based on which the sample size was determined in case of sample loss. Thus, using the ralloc module (Random allocation of treatments in controlled trials) in Stata software, random samples were determined for study. 3 Osteonecrosis. Intervention 1: Intervention group: Includes patients whose multi-target therapies such as atorvastatin 40 mg daily, vitamin E (400 mg) daily, and aspirin 80 mg daily are added to their bisphosphonate (alendronate 70 mg weekly) to prevent osteonecrosis. Intervention 2: Control group: This includes patients who have added 70 mg alendronate weekly to the patient's treatments. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information