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IRCT20201121049457N1 IRCT 2021-09-14 Mashhad University of Medical Sciences Effect of curcumin on the intensity of dysmenorrhea pain Investigating the effect of curcumin on the intensity of dysmenorrhea pain in endometriosis patients 2021-09-11 anticipated 50 Complete https://irct.ir/trial/58098 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients are randomly divided into two groups of intervention and placebo. The intervention group receives two oral capsules of 40 mg curcumin (Cinacurcumin, Minoo Pharmaceutical Company, Tehran, Iran) for three months and from the same day (the first day of the menstrual cycle) and the control group receives two, Blinding description: This is a three-blind study in which the patient, the physician evaluating the outcome, and the outcome analyzer will not be aware of patient grouping. Blinding is done with the help of closed envelopes and randomization is done with the help of a random number table and the envelopes are provided to the patients by the secretary of the clinic. 3 Endometriosis. Intervention 1: Intervention group: daily administration of two 40 mg curcumin capsules in the intervention group for three months. Intervention 2: Control group: two placebo capsules in the control group for three months and Placebo composed of nanomicels. Yes - There is a plan to make this available What will be shared: All data can be shared after patients are made unidentifiable. When: Data can be accessible 6 months after results are published. To whom: Data can be accessible through an email to the correspounding author. Conditions: Data will be available for researchers in universities and other scientific institutes. Where to obtain: After sending a request email to the correspounding author, data will be sent in 1 month. How to obtain: Carrying out analysis on data is permitted. Comments:
public Shima Hatami
Imam Reza Hospital, Imam Reza Hospital Square
Mashhad Iran (Islamic Republic of) 9137913316 +98 51 3802 2608 shima.hatami69@gmail.com Mashhad University of Medical Sciences scientific Malihe Amirian
Imam Reza Hospital, Imam Reza Hospital Square
Mashhad Iran (Islamic Republic of) 9137913316 +98 51 3802 2608 Amirianm@mums.ac.ir Mashhad University of Medical Sciences Iran (Islamic Republic of) Diagnosis of endometriosis based on ultrasound, MRI or surgery (based on persistent cysts or typical endometriosis profile) Complaints of dysmenorrhea Age 15-45 years old Informed written consent to participate in the study 15 years 45 years Female Treatment with GnRH agonist drugs Intention to get pregnant N80 Endometriosis Treatment - Drugs Placebo Intervention group: daily administration of two 40 mg curcumin capsules in the intervention group for three months. Control group: two placebo capsules in the control group for three months and Placebo composed of nanomicels Severe dysmenorrhea pain. Timepoint: Once every seven days. Method of measurement: By 10-point visual analogue scale (VAS). Mashhad University of Medical Sciences Approved 2021-08-15 Ethics committee of Mashhad university of Medical Sciences Central Building of Mashhad University of Medical Sciences (Ghorshi), Daneshgah 16, Daneshgah street Mashhad Razavi Khorasan Iran (Islamic Republic of)