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IRCT201012185414N1 IRCT 2011-08-24 Vice chancellor for research, Kashan University of Medical Sciences Comparison of Labetalol versus Hydralazin in control of Hypertension in preeclamptic patients and the out come of their pregnancy Comparison of Labetalol versus Hydralazin in control of Hypertension in preeclamptic patients and the out come of their pregnancy 2009-04-20 anticipated 190 Complete https://irct.ir/trial/5811 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. 2-3 preeclampsia. Intervention 1: Hydralazin prescription in a 5 mg dose as first dose and blood pressure control after 20 minutes by first degree resident and repeat the same dose every 20 minutes up to 3 doses. Intervention 2: Labetalol prescription in a 20 mg dose as first dose and blood pressure control after 20 minutes by first degree resident and repeat the complimentary doses as 40 mg and 80 mg every 20 minutes up to 3 doses.
public Dr.Zohreh Tabasi
Shabihkhani Hospital, Beheshti avenue
Kashan Iran (Islamic Republic of) +98 36144460180 tabasi_z @kaums.ac.ir; narges_oghbaee@yahoo.com Kashan University of Medical Sience scientific Dr.Zohreh Tabasi
Shabihkhani Hospital, Beheshti avenue
Kashan Iran (Islamic Republic of) +98 36144460180 tabasi_z@kaums.ac.ir; narges_oghbaee@yahoo.com Kashan University of Medical Science Iran (Islamic Republic of) Every pregnant woman by gestational age 20 to 42 weeks with a BP>160/105, singleton, estimated fetal weight < 4500 g Exclusion criteria: 1. History of basic chronic diseases ,including chronic HTN, hyperthyroidism, arrhythmia 2. Non cephalic presentation, macrosomia, thick meconium, previous history of caesarian section or uterine rupture which abdicate the option of NVD of patients. 3. History of long infertility, stillbirth, anomalous child, every reason for high risk pregnancy. 15 years 45 years Female 016-010 ادم, پروتئینوری و اختلالات فشار خون در حاملگی, وضع حمل و نفاس Treatment - Drugs Treatment - Drugs Hydralazin prescription in a 5 mg dose as first dose and blood pressure control after 20 minutes by first degree resident and repeat the same dose every 20 minutes up to 3 doses Labetalol prescription in a 20 mg dose as first dose and blood pressure control after 20 minutes by first degree resident and repeat the complimentary doses as 40 mg and 80 mg every 20 minutes up to 3 doses Hydralazin effect on control of Hypertension. Timepoint: 20minuts. Method of measurement: Mercurial Barometer. Labetalol effect on control of Hypertension. Timepoint: 20 minutes. Method of measurement: Mercurial Barometer. Maternal pulse rate control. Timepoint: 20minutes. Method of measurement: Maternal pulse rate control. Average decreased amount of systolic blood pressure after Hydralazin administration. Timepoint: 20 minutes. Method of measurement: Mercurial Barometer. Average decreased amount of diastolic blood pressure after Hydralazin administration. Timepoint: 20 minutes. Method of measurement: Mercurial Barometer. Vice chancellor for research, Kashan University of Medical Sciences Approved 2010-11-24 Kashan University of Medical Science; Ethics committee Pezeshk blvd, Ghotbe Ravandi blvd, Kashan Iran (Islamic Republic of)