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IRCT20101006004877N29 IRCT 2021-10-07 Vice chancellor for research, Faculty of Dentistry, Isfahan University of Medical Sciences Effect of hydrogen peroxide and zinc mouth-wash in reducing gingival inflammation Effect of hydrogen peroxide and zinc mouth-wash on periodontal indices in patients with chronic gingivitis in randomized clinical trial. 2021-09-23 anticipated 64 Complete https://irct.ir/trial/58204 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Randomization method is based on simple decomposition method which is done by lottery method. In this way, 44 envelopes are sealed, in which the four codes related to each of the experimental groups are prepared, and each participant randomly selects one of these envelopes and The base of the code inside the envelope is in one of the test groups, Blinding description: In three groups that take mouthwash , mouthwash in the same battles but for reducing ignores , corks of battle manufacturing in three colors. The colors have a code that just researcher have known the codes refer to what kind of mouthwash. 3 Gingivitis. Intervention 1: Control group: This group is considered as a positive control group and people in this group will not use mouthwash. Intervention 2: Intervention group: People in this group are asked to use 0.2% chlorhexidine mouthwash twice a day at a rate of 5 ml for 2 weeks. Intervention 3: Second Intervention group: In this group, people are asked to use 5 ml of hydrogen peroxide mouthwash twice a day for 2 weeks. Intervention 4: third Intervention group: In this group, people are asked to use placebo mouthwash twice a day in the amount of 5 ml for 2 weeks. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is No more information
public Jaber Yaghini
Hezar Jerib St., Isfahan University of Medical Sciences and Health Services, ‌Dental School
Isfahan Iran (Islamic Republic of) 8174673461 +98 31 3792 5542 J_yaghini@dnt.mui.ac.ir Esfahan University of Medical Sciences scientific Jaber Yaghini
Hezar Jerib St., Isfahan University of Medical Sciences and Health Services, ‌Dental School
Isfahan Iran (Islamic Republic of) 8174673461 +98 31 3792 5564 J_yaghini@dnt.mui.ac.ir Esfahan University of Medical Sciences Iran (Islamic Republic of) 15 functional teeth at least Gingivitis in gingival. ( gingival index at least 2 or more ) Don’t use alcohol and cigarettes non-existence of systemic diseases that effect gingiva condition l Don’t use drugs that effect periodontal condition Non-existence of periodontal surgery or condition that effect periodontal diseases 14 years 64 years Both People with dental anomalies People over the age of 65 People with a history of orthodontic treatment People with a history of bleaching treatment. K05.1 Chronic gingivitis Treatment - Drugs Treatment - Drugs Treatment - Drugs Treatment - Drugs Control group: This group is considered as a positive control group and people in this group will not use mouthwash. Intervention group: People in this group are asked to use 0.2% chlorhexidine mouthwash twice a day at a rate of 5 ml for 2 weeks. Second Intervention group: In this group, people are asked to use 5 ml of hydrogen peroxide mouthwash twice a day for 2 weeks. third Intervention group: In this group, people are asked to use placebo mouthwash twice a day in the amount of 5 ml for 2 weeks. Decrease in probing death. Timepoint: In the beginning of research- 2 weeks- 6 weeks- 3 months. Method of measurement: By periodontal probe in the mid buccal tooth gingival. Plaque index. Timepoint: In the beginning of research- 2 weeks- 6 weeks- 3 months. Method of measurement: For indicating plaque index , using silness&leo plaque index . In this index , 0 demonstrative no microbial plaque , 1 demonstrative a thin layer of plaque in around of free marginal gingival, 2 demonstrative the medium amount of plaque in gingival sulcus and 3 demonstrative large amount of plaque in sulcus or periodontal pocket till free gingival margin. Probing bleeding index. Timepoint: In the beginning of research- 2 weeks- 6 weeks- 3 months. Method of measurement: In this criterion, zero indicates the absence of bleeding, one indicates the presence of a specific bleeding point, two indicates the presence of isolated bleeding points in several cases or the presence of a single line of bleeding, three indicates that after probing the triangle between A tooth is immediately filled with blood, and a score of 4 in this index indicates heavy bleeding after probing, which immediately flows into the marginal sulcus. Gingival index. Timepoint: In the beginning of research- 2 weeks- 6 weeks- 3 months. Method of measurement: To determine the gingivitis index (GI) of patients, the 4-part Leo & Silness criterion is used, in which zero indicates normal gingiva, one indicates mild inflammation (slight changes in color and mild edema with bleeding during probing), two indicates moderate inflammation. Along with edema redness and bleeding during probing and three also indicate severe inflammation with severe edema redness and ulceration and tendency to bleed simultaneously. Vice chancellor for research, Faculty of Dentistry, Isfahan University of Medical Sciences Approved 2021-08-23 Ethics Committee of Isfahan University of Medical Sciences Hezar Jerib St., Isfahan University of Medical Sciences and Health Services, Ethics Committee isfahan Isfehan Iran (Islamic Republic of)