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IRCT20210819052231N1 IRCT 2022-04-04 University of social welfare and rehabilitation sciences The effect of transcranial direct current stimulation (tDCS) on cognition in people with MS tDCS, MS The effect of transcranial direct current stimulation(tDCS) on attention, working memory and information processing speed in people with MS 2022-06-20 anticipated 36 Complete https://irct.ir/trial/58217 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Factorial, Purpose: Treatment, Other design features: In this study, three groups will be examined. A group called the intervention group will receive the intervention along with tDCS. The control group one will receive intended intervention with sham tDCS. Control group two will only receive the intervention without any stimulation, Randomization description: After selecting all samples for dividing them into groups as intervention experimental, control 1 and control 2 we will use the SAS application and the PROC SURVEYSELECT process, which is for generating a random sequence for experiments with more complex designs, including factorial experiments, Blinding description: Participants, outcome assessors and data analysts will be unaware of how people are grouped. N/A Multiple sclerosis. Intervention 1: Intervention group first: Cognitive rehabilitation program (including routine rehabilitation exercises in occupational therapy clinics) in addition to tDCS stimulation (20 minutes of two milliampere current applied through the anode electrode on the scalp of the prefrontal dorsultral region and the cathode electrode upper of right eyebrow ) 4 times a week for three weeks. The duration of each session will be 45 minutes. Intervention 2: Intervention group second: The tDCS is used artificially (placing the anode and cathode electrodes on the scalp for 20 minutes, establishing a 2 mA current for 10 seconds, and then cutting off the current for the next 10 seconds) with a cognitive rehabilitation program. 4 times a week for three weeks and the duration of each session will be 45 minutes. Intervention 3: Control group: Only the cognitive rehabilitation program runs. They will receive 4 times a week for three weeks and the duration of each session will be 45 minutes. Yes - There is a plan to make this available What will be shared: All data is potentially shareable after unidentifiable individuals When: Access period starts 6 months after the results are published To whom: All individuals, including researchers working in academic and scientific institutions and those working in the clinic, can apply for the data. Conditions: The data will be provided to researchers for further studies or to use this data for related research. Where to obtain: Hamideh Aghachavoshi Email Address: aghachavoshi_hamide@yahoo.com Address: Unit 4, Block 33/2, Eram Dead End, Besharat St., Hakimieh, Tehran Phone: 09137729652 Dr. Hojjatullah Haghgoo Email Address: H.haghgoo@yahoo.com Address: Department of Occupational Therapy, University of Rehabilitation and Social Health, Koodakiar St., Daneshjoo Blvd., Evin, Tehran Phone: 02122180063 How to obtain: Files and documents will be provided to the applicant through correspondence and application to the Department of Occupational Therapy of the University of Rehabilitation Sciences and Social Welfare and the approval of the director and deputy director of the Department of Occupational Therapy. Comments:
public Hamide Aghachavoshi
Kodakyar Ave., Daneshjo Blvd., Evin, Tehran
Tehran Iran (Islamic Republic of) 1985713871 +98 21 7730 3532 hm.aghachavoshi@uswr.ac.ir University of social welfare and rehabilitation sciences scientific Hamide Aghachavoshi
Kodakyar Ave., Daneshjo Blvd., Evin, Tehran
Tehran Iran (Islamic Republic of) 1985713871 +98 21 7730 3532 hm.aghachavoshi@uswr.ac.ir University of social welfare and rehabilitation sciences Iran (Islamic Republic of) Willing to participate in research Have a definitive diagnosis of MS by a specialist doctor EDSS score should be from 1 to 6 The person has no history of dementia and other psychotic illnesses There is no Recurrence of relapsing while doing the study Do not take corticosteroids for 28 days before the intervention Have no history of other neurological diseases 20 years 50 years Both Do not complete the intervention Recurrence of relapsing occurs during the intervention G35 Multiple sclerosis Rehabilitation Rehabilitation Rehabilitation Intervention group first: Cognitive rehabilitation program (including routine rehabilitation exercises in occupational therapy clinics) in addition to tDCS stimulation (20 minutes of two milliampere current applied through the anode electrode on the scalp of the prefrontal dorsultral region and the cathode electrode upper of right eyebrow ) 4 times a week for three weeks. The duration of each session will be 45 minutes. Intervention group second: The tDCS is used artificially (placing the anode and cathode electrodes on the scalp for 20 minutes, establishing a 2 mA current for 10 seconds, and then cutting off the current for the next 10 seconds) with a cognitive rehabilitation program. 4 times a week for three weeks and the duration of each session will be 45 minutes. Control group: Only the cognitive rehabilitation program runs. They will receive 4 times a week for three weeks and the duration of each session will be 45 minutes. Score obtained for attention in the Paired Associate Learning test. Timepoint: Measurement of attention at the beginning of the study and after three weeks and 2 months after the intervention. Method of measurement: Paired Associate Learning test. Score obtained for working memory in the Spatial Span test. Timepoint: Measurement of working memory at the beginning of the study and after three weeks and 2 months after the intervention. Method of measurement: Spatial Span test. Score obtained for data processing speed in Paced Auditory Serial Addition Test. Timepoint: Measurement of information processing speed at the beginning of the study and after three weeks and 2 months after the intervention. Method of measurement: Paced Auditory Serial Addition Test. University of social welfare and rehabilitation sciences Approved 2022-02-19 Ethics committee of University of Social Welfare and Rehabilitation University of Rehabilitation Sciences and Socia Health, Koodkiar St., Daneshjoo Blvd., Evin, Tehran Tehran Iran (Islamic Republic of)