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IRCT20210822052256N2 IRCT 2022-03-17 Esfahan University of Medical Sciences The effect of left breast radiotherapy on the heart. Global Longitudinal Strain, Left Ventricle Ejection Fraction Evaluation of the relationship between mean heart dose in left breast cancer radiation therapy with Pro-BNP and Troponin values and left ventricular systolic function based on LVEF and GLS values in echocardiography. 2022-01-15 anticipated 37 Complete https://irct.ir/trial/58307 interventional Randomization: N/A, Blinding: Not blinded, Placebo: Not used, Assignment: Single, Purpose: Diagnostic. 2 Heart Failure. Intervention group: Women with left breast cancer who are treated with conventional 3D or hypofractionated radiation therapy with a dose of 50 Gy in 25 fractions or 42.5 Gy in 16 fractions.. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is No more information.
public Ali Akhavan
Radiation Oncology Department, Seyed-alshohada (Omid) Hospital, Motahari Ave.,
Isfahan Iran (Islamic Republic of) 8184917911 +98 31 3235 0210 aliakhavan@med.mui.ac.ir Esfahan University of Medical Sciences scientific Ali Akhavan
Radiation Oncology Department, Seyed-alshohada (Omid) Hospital, Motahari Ave.,
Isfahan Iran (Islamic Republic of) 8184917911 +98 31 3235 0210 aliakhavan@med.mui.ac.ir Esfahan University of Medical Sciences Iran (Islamic Republic of) All patients with left breast cancer over the age of 18 that have undergone left breast radiation therapy at Omid Hospital Have not received chemotherapy or just received the TC (taxane-cyclophosphamide) chemotherapy regimen 18 years no limit Both Patients under 18 years old Patients with end stage or metastatic malignancy Patients with two synchronous cancers Patients with a history of heart failure with LVEF≤50% or a history of valvular heart disease or advanced congenital heart disease or proven coronary artery disease Patients with a history of chest radiation therapy Pregnant patients with breast cancer Patients receives or have received of anthracyclines and trastuzumab I50.2 Systolic (congestive) heart failure Treatment - Other Intervention group: Women with left breast cancer who are treated with conventional 3D or hypofractionated radiation therapy with a dose of 50 Gy in 25 fractions or 42.5 Gy in 16 fractions. Heart mean dose in radiation therapy for left breast cancer. Timepoint: Before and 6 months after left breast radiotherapy. Method of measurement: Dose volume histogram. Troponin. Timepoint: Before and just after left breast radiotherapy. Method of measurement: Laboratory test. Brain natriuretic peptide. Timepoint: Before and just after left breast radiotherapy. Method of measurement: Laboratory test. Left ventricle ejection fraction. Timepoint: Before and just after left breast radiotherapy. Method of measurement: Echocardiography. Global longitudinal strain. Timepoint: Before and just after left breast radiotherapy. Method of measurement: Echocardiography. Esfahan University of Medical Sciences Approved 2021-08-20 Research Ethics Committees of School of Medicine-Isfahan University of Medical Sciences Motahari Ave, Omid Hospital Isfahan Isfehan Iran (Islamic Republic of)