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IRCT20210730052019N2 IRCT 2021-08-28 Kerman University of Medical Sciences Effect of low-dose aspirin on OHSS Effect of low-dose aspirin before IVF to prevent ovarian hyperstimulation syndrome (OHSS) 2021-08-25 anticipated 20 Complete https://irct.ir/trial/58308 interventional Randomization: N/A, Blinding: Not blinded, Placebo: Not used, Assignment: Single, Purpose: Prevention, Other design features: The intervention group will be recruited in this study. For the control group, existing data will be used. The control group in this study consists of patients with PCO criteria who had previously undergone IVF with the same regimen as Intervention group (Except for ASA). Data of this group is extracted from patients files in infertility ward of Kerman Afzalippor Hospital and will be used as the control to compare the outcomes of OHSS in intervention group. These patients, regarding the aforementioned criteria, will be selected using random sampling. Therefore, in this study, patient recruitment will occur for intervention group. 2 Infertility. Intervention group: The study will be conducted in Kerman Afzalipoor Hospital. The intervention group will be administered low dose ASA two weeks before the start of menstural cycle and will recieve Cinnal-F on day 3 of the cycle and after 6 days, on 9th day of the cycle, vaginal sonography will be performe. As the follicle size reached 12 to 14 mm, antagonist will be administered and as the size of follicles reached 16-18 mm, 1 cc Buserelin and 5000 units of hcg will be administered and 36 hours later, ovarian punction will be done. Patients will be given charts to follow their OHSS related symptoms. Three days after the punction, laboratory and sonographic data will be obtained and evaluated.. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information
public Victoria Habibzadeh
imam khomeini highway, Afzalipoor Hospital
kerman Iran (Islamic Republic of) ۷۶۱۶۹۱۳۹۱۱ +98 34 3132 8000 v_habibzadeh@kmu.ac.ir Kerman University of Medical Sciences scientific Victoria Habibzadeh
imam khomeini highway, Afzalipoor Hospital
kerman Iran (Islamic Republic of) ۷۶۱۶۹۱۳۹۱۱ +98 34 3132 8000 v_habibzadeh@kmu.ac.ir Kerman University of Medical Sciences Iran (Islamic Republic of) Female patients planned to treat with anatgonist protocol ART (Assisted Reproductive Technology) Having PCO criteria (Including AMH level more than 4 ng/ml, Sonogram suggestive of PCO, and Oligomenorrhea) no limit no limit Female Lack of consent to participate N97 Female infertility Prevention Intervention group: The study will be conducted in Kerman Afzalipoor Hospital. The intervention group will be administered low dose ASA two weeks before the start of menstural cycle and will recieve Cinnal-F on day 3 of the cycle and after 6 days, on 9th day of the cycle, vaginal sonography will be performe. As the follicle size reached 12 to 14 mm, antagonist will be administered and as the size of follicles reached 16-18 mm, 1 cc Buserelin and 5000 units of hcg will be administered and 36 hours later, ovarian punction will be done. Patients will be given charts to follow their OHSS related symptoms. Three days after the punction, laboratory and sonographic data will be obtained and evaluated. OHSS Incidence. Timepoint: Throughout the study based on patients symptoms or on the third day after punction based on laboratory and sonographic findings. Method of measurement: Patient symptoms montioring sheets - Laboratory findings (Rise of liver enzymes, creatinine, hematocrit), sonographic findings (ascites). OHSS Severity. Timepoint: Throughout the study based on patients symptoms or on the third day after punction based on laboratory and sonographic findings. Method of measurement: Patient symptoms montioring sheets - Laboratory findings (Rise of liver enzymes, creatinine, hematocrit), sonographic findings (ascites). Kerman University of Medical Sciences Approved 2020-05-12 Ethics committe of Kerman University of Medical Sciences Haftbagh-Alavi highway, Kerman University of medical Sciences Kerman Kerman Iran (Islamic Republic of)