IRCT20201028049175N9 IRCT 2021-09-06 Arak University of Medical Sciences Effect of Selenium on improvement of clinical manifestations and reducing hospitalization in patients with COVID 19 Effect of Selenium on improvement of clinical manifestations and reducing hospitalization in patients with COVID 19 2021-09-22 anticipated 160 Complete https://irct.ir/trial/58485 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Sequences web randomization (www.graphpad.com) dual group for creation of simple randomization and for concealment, closed envelope method with random sequence (SNOSE) will be used. Random sequences will be written on the cards and then sequentially put in the envelopes. In order to preserve random sequences, the outer surface of the envelopes are numbered, respectively. Finally, the lid of the envelopes will be paste and place inside the boxes, respectively. At the time of participants registration, one of the envelopes will be open and the allocation group will be revealed, Blinding description: All patients have informed consent to entrance to study, but they do not know about the kind of drugs have been received . The required drugs will be prescribed by the infectionist and anesthesiologist, but the person who will gather the data of patients outcomes will be unaware about the patients group and the kind of received drugs. 3 Condition 1: Coronavirus disease 2019 (COVID 19). Condition 2: Selenium. Intervention 1: Intervention group: 1 mg of selenium intravenously will be injected for 14 days added to routine treatment protocol. Intervention 2: Control group: Distilled water that is similar to Selenium will be given to the patients for 14 days (in addition to routine treatment). Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There are no more data.