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IRCT20191123045476N3 IRCT 2021-12-01 Iran University of Medical Sciences The effect of PRP on ovarian reserve The effect of autologous PRP on ovarian reserve in patients undergoing laparoscopic endometriosis surgery 2021-12-11 anticipated 30 Complete https://irct.ir/trial/58688 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Supportive, Randomization description: اn this study, restricted randomization sampling method is used that the study groups have equal sample size. Random allocation rule is one of the limited random sampling methods used in the present study. And patients are equally divided into two groups. On how to randomize, researchers first determine a total sample size, then randomly assign a set of them to group A and the rest to group B. For example, in a study with a sample size of 200 people, 100 balls For intervention group A and 100 balls, for intervention group B, it is placed in a lottery container and then the balls are randomly removed from the container without replacement and the created sequence is recorded. This method is used for two or more group trials. 3 Laparoscopy of endometriosis. Intervention 1: Intervention group: the patient is injected with concentrated plasma, which is rich in platelets, according to the study protocol. Before the operation, 20 cc of the patient's blood is taken in a PRP tube (GeoPRP-regenlab kit). The tube is completely shaken and its contents are centrifuged at 3600 rpm for 6 minutes and the surface PRP is collected with a 16-gauge needle. The result is about 4-8 cc of PRP. After laparoscopy cystectomy, 2-4 cc is injected subcortically into the ovary with endometrial cyst. Intervention 2: Control group: In the control group, endometriosis patients with ovarian cysts undergo only laparoscopic surgery and PRP injection is not performed. Yes - There is a plan to make this available What will be shared: Following the publication of the article, confidential information such as patient profile and Hospital, ... deletion and other information Will be made available to researchers When: After publishing the article To whom: Medical specialists Conditions: Medical professionals can turn to data for research purposes gain access Where to obtain: Refer to the email of the responsible author How to obtain: Official and academic email to the responsible author Comments:
public Samaneh Rokhgireh
Sattar Khan .Mansouri St. Rasoul Akram Hospital
Tehran Iran (Islamic Republic of) 1445613131 +98 21 6435 1000 s.rokhgireh@gmail.com Iran University of Medical Sciences scientific Samaneh Rokhgireh
Sattar Khan .Mansouri St. Rasoul Akram Hospital
Tehran Iran (Islamic Republic of) 1445613131 +98 21 6435 1000 s.rokhgireh@gmail.com Iran University of Medical Sciences Iran (Islamic Republic of) Endometriosis women are candidates for laparoscopic surgery with a diameter of 4 to 10 cm, which is confirmed by ultrasound BMI between 18.5 and 30 have. Have not received hormonal drugs, especially GnRH agonists, in the last 3 months. AMH should be less than 1/1 ng. 20 years 35 years Female Women with a body mass index (BMI) greater than 30 or less than 18/5 People with autoimmune disorders and malignancies People with sexually transmitted and infectious diseases People with infertility following tubal obstruction and patients with endocrine disorders such as thyroid dysfunction Patients who use anticoagulant drugs N80 Endometriosis Treatment - Drugs Treatment - Surgery Intervention group: the patient is injected with concentrated plasma, which is rich in platelets, according to the study protocol. Before the operation, 20 cc of the patient's blood is taken in a PRP tube (GeoPRP-regenlab kit). The tube is completely shaken and its contents are centrifuged at 3600 rpm for 6 minutes and the surface PRP is collected with a 16-gauge needle. The result is about 4-8 cc of PRP. After laparoscopy cystectomy, 2-4 cc is injected subcortically into the ovary with endometrial cyst. Control group: In the control group, endometriosis patients with ovarian cysts undergo only laparoscopic surgery and PRP injection is not performed. ََAMH hormone level. Timepoint: 6 months after surgery. Method of measurement: Blood test. Number of Antral Follicles (AFC). Timepoint: 6 months after surgery. Method of measurement: Sonography. Iran University of Medical Sciences Approved 2021-09-12 Ethics Committee of Iran University of Medical Sciences Sattar Khan St., Maziar Mansouri St., Rasoul Akram Hospital Tehran Tehran Iran (Islamic Republic of)