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IRCT20180217038763N3 IRCT 2021-10-02 Mashhad University of Medical Sciences Evaluation the effectiveness of isotretinoin in people with rhinoplasty with thick and oily skin Evaluation the efficacy of topical isotretinoin after rhinoplasty in people with thick and oily skin of the nose 2021-10-07 anticipated 40 Complete https://irct.ir/trial/58849 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Supportive, Randomization description: Simple randomization with table of random numbers available at ''www.randomization.com'' website will be used. Numbers will be placed in sealed envelopes and each envelope is assigned to one participant placing them in one of the two groups, Blinding description: The subjects and those evaluating the outcome will be unaware of the intervention and control groups. 3 rhinoplasty. Intervention 1: Intervention group: In this group, in addition to routine treatment, 1 month after surgery patients are treated with 0.05% isotretinoin gel (every night) and the condition of nasal edema is evaluated 1, 3 and 6 months after consumption. Intervention 2: Control group: In this group, routine recommendations include using oil-free sunscreen and skin trauma care and seeing a doctor in case of any side effects. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is After finishing work, consult with colleagues and it will be published if all members
public Morteza Noorollahian Mohajer
Ghaem Hospital, Ahmad Abad AVE
Mashhad Iran (Islamic Republic of) 99199-91766 +98 51 3841 3492 Noorollahianm@mums.ac.ir Mashhad University of Medical Sciences scientific Morteza Noorollahian Mohajer
Ghaem Hospital, Ahmad Abad AVE
Mashhad Iran (Islamic Republic of) 99199-91766 +98 51 3841 3492 Noorollahianm@mums.ac.ir Mashhad University of Medical Sciences Iran (Islamic Republic of) Candidates for rhinoplasty who have thick and oily skin of the nose Conscious consent to participate in the study 18 years 50 years Both Use of other medications in addition to prescribed medications Decide to get pregnant from one month before starting to one month after finishing Breastfeeding Dry and sensitive skin Incidence of skin allergies Use of drugs which have been shown to interact with isotretinoin M95.0 Acquired deformity of nose Treatment - Other Treatment - Other Intervention group: In this group, in addition to routine treatment, 1 month after surgery patients are treated with 0.05% isotretinoin gel (every night) and the condition of nasal edema is evaluated 1, 3 and 6 months after consumption. Control group: In this group, routine recommendations include using oil-free sunscreen and skin trauma care and seeing a doctor in case of any side effects. Edema and nasal ecchymosis. Timepoint: 1month, 3 months and 6 months after surgery. Method of measurement: By an ENT specialist. Mashhad University of Medical Sciences Approved 2019-10-22 Ethics committee of Mashhad University of Medical Science Central Building of Mashhad University of Medical Sciences (Ghorshi), Daneshgah 16, Daneshgah Street Mashhad Razavi Khorasan Iran (Islamic Republic of)