IRCT20180613040083N1 IRCT 2022-06-10 Shahre-kord University of Medical Sciences Evaluation of the Effect of Melissa Officinalis L ( Lemon Balm) Capsule on Cognitive Impairment in Depressed Patients Treated With ECT Evaluation of the Effect of Melissa Officinalis L ( Lemon Balm) Capsule on Cognitive Impairment in Depressed Patients Treated With ECT 2022-10-22 anticipated 80 Complete https://irct.ir/trial/58948 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: To randomly assign individuals to two groups, using the randomization Replacement blocks method were used. By using the software, a random block of fifteen blocks with a volume of six was designed and a randomization list was provided to the researchers. In each of the 70 blocks are written two letters, a, two letters b, a which means intervention group and b means control group, Blinding description: The study is a double-blind study, in which the project implementer and the patients are not aware of the process and drugs, and the data analyst is not aware of the drug used. 3 Major Depression , ECT. Intervention 1: Intervention group: 40 depressed patients treated with ECT, receiving 500mg lemon balm capsules (made by the Made by a pharmacologist) every 8 hours after a month Evaluation with questionnaire. Intervention 2: Control Group: 40 depressed patients treated with ECT, receiving 500mg placebo capsules (made by the Made by a pharmacologist) every 8 hours after a month Evaluation with questionnaire. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is A decision will be made later