IRCT20150706023084N11 IRCT 2021-10-10 Islamic Azad University Randomize comparison of vaginal suppository containing cuminum cyminum essential oil with vaginal clotrimazole versus placebo vaginal suppository for vulvovaginal candidiasis treatment Randomize comparison of vaginal suppository containing cuminum cyminum essential oil with vaginal clotrimazole versus placebo vaginal suppository for vulvovaginal candidiasis treatment 2021-10-05 anticipated 60 Complete https://irct.ir/trial/58977 interventional Randomization: N/A, Blinding: Single blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Blinding description: vaginal suppositories of cuminum cyminum and placebo were made by the researcher and were placed in aluminum foils individually , and everyone except the researcher was unaware of the composition of these drugs. 1 Candidiasis vulvovaginitis. Intervention 1: Intervention group: consist of 30 people who each receive a 2 gram vaginal suppository containing 0.1 cc of cuminum cyminum essential oil along with clotrimazole vaginal suppository daily for seven days (clotrimazole at night and cuminum cyminum suppository in the morning or noon). Cuminum cyminum suppository is based on polyethylene glycol 1000 and 4000 at the rate of 80% and 20% which is made in Tehran Azad University of Medical Sciences, Department of Pharmacy and Pharmaceutical Sciences. Participants will be explained how to use the drug at the beginning of the study . Intervention 2: Control group: Including 30 patients, each receiving a clotrimazole vaginal suppository and a placebo suppository daily for seven days (clotrimazole at night and placebo in the morning or at noon). Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is 1. Do not misuse information in similar research and data processing according to them 2. Because the results are reported in thesis, it is not necessary to publish raw data.