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IRCT201012295497N1 IRCT 2013-01-12 Vice chancellor for research, Hamedan University of Medical Sciences and Health Services Assessing the effect of serum therapy on decreasing of icterus Effect of Intravenous Fluid therapy on decreasing serum bilirubin during intensive phototherapy in healthy term neonate with severe non hemolytic hyperbilirubinemia in comparison with phototherapy alone 2011-06-01 anticipated 160 Complete https://irct.ir/trial/5899 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. 3 Neonatal jaundice. Intervention 1: One hundred sixty neonates with hyperbilirubinemia who were admitted at neonate ward of Besat hospital of Hamedan, Iran and who are breast feeding were divided to two groups. Eighty neonates in intervention group receive 70 cc per kg of ⅓-⅔serum daily with phototherapy (together) . The serum that was used, contains sodium as ⅓of normal saline and glucose as of ⅔dextrose 5% and use this serum intravenous until total bilirubin being less than 17. This serum made in Tehran Darou Company. Intervention 2: One hundred sixty neonates with hyperbilirubinemia who were admitted at neonate ward of Besat hospital of Hamedan, Iran and who are breast feeding were divided to two groups. Eighty neonates (control) receive only phototherapy alone.
public Abbas Moein
Hamedan Besat Hospital
Hamedan Iran (Islamic Republic of) +98 81 1264 0050 a.moein@umsha.ac.ir Hamedan University of Medical Sciences scientific Abbas Moein
Hamedan Besat Hospital
Hamedan Iran (Islamic Republic of) +98 81 1264 0050 a.moein@umsha.ac.ir Hamedan University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: 1.Term neonate (between 37 and 42 weeks of neonatal age ). 2. All neonates between 2 and 28 days of old age 3. 17< total serum bilirubin <25 . 4. 2500 g < weight< 4000 g 5. Without congenital anomaly and systemic diseases (sepsis, anemia, hemolysis, HMD). Exclusion criteria: 1. Neonate <37 weeks of old age 2. Congenital anomaly, systemic disease (sepsis, HMD. pneumonia, anemia, hemolysis) 3.Demand to blood exchange 4. 4000 g <Weight< 2500 g . 5. Neonates who in first ten days of life loss more than 3% of weight. 2 years 28 years Both P59 Neonatal jaundice from other and un specified causes Treatment - Other Early detection One hundred sixty neonates with hyperbilirubinemia who were admitted at neonate ward of Besat hospital of Hamedan, Iran and who are breast feeding were divided to two groups. Eighty neonates in intervention group receive 70 cc per kg of ⅓-⅔serum daily with phototherapy (together) . The serum that was used, contains sodium as ⅓of normal saline and glucose as of ⅔dextrose 5% and use this serum intravenous until total bilirubin being less than 17. This serum made in Tehran Darou Company. One hundred sixty neonates with hyperbilirubinemia who were admitted at neonate ward of Besat hospital of Hamedan, Iran and who are breast feeding were divided to two groups. Eighty neonates (control) receive only phototherapy alone. Indirect bilirubin. Timepoint: During at 6, 12, 24, 48 and 72 hours after beginning of phototherapy. Method of measurement: Measuring serum bilirubin(diazo method). Age. Timepoint: Between 2 and 28 days of old age. Method of measurement: Since birthday. Duration of hospitalization. Timepoint: 6- 12- 24- 48 and 72 hours after phototherapy. Method of measurement: Hours. Sex. Timepoint: Beginning of study. Method of measurement: Physical examination. Blood group. Timepoint: Beginning of study. Method of measurement: Laboratory test. Vice chancellor for research, Hamedan University of Medical Sciences and Health Services Approved 2011-05-14 Ethics committee of Hamedan University of Medical Sciences and Health Services Opposite Mardom Park, Shahid Fahmide Ave, Mahdieh Ave, Hamedan Hamedan Iran (Islamic Republic of)