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IRCT20211023052848N1 IRCT 2021-11-17 Bandare-abbas University of Medical Sciences Comparison of the effect of dexmedetomidine and lidocaine on fentanyl induced cough Comparison of the effect of dexmedetomidine and lidocaine on fentanyl induced cough in patients undergoing elective surgery 2021-11-21 anticipated 171 Complete https://irct.ir/trial/59528 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Epidemiologist download the random allocation software from http://random-allocation-software-inform.com,which this random sequence generation software in addition to randomization is able to generate random sequences in different ways.Simple randomization was done in each group through random allocation software (version 1.0.0 ) and entered the number of groups,sample size and group name into main windows icon,then a sequence of 171 cases(equal to sample size) was created using the Rnd function that the patients randomly and based on this random sequence table,enter to one of groups, Blinding description: To blind patients, the first group will receive the equivalent volume of lidocaine from normal saline solution 90 seconds before the prodrug and the second and third group patients will receive 10 ml of isotonic salibene 10 minutes before the prodrug administration. All this information will be provided by an anesthesia assistant who does not know the grouping and how to inject the drugs. Because the patients are also unaware of the groups, the study is double-blind. 3 fentanyl indeuced cough. Intervention 1: Intervention group 1: Lidocaine: 1.5 mg / kg intravenously for 90 seconds before fentanyl injection. Intervention 2: Intervention group: Intervention group 2: Dexmedetomidine: 0.5 μg / kg solution of 10 cc of isotonic saline 10 minutes before anesthesia, by infusion. Intervention 3: Control group: normal saline at a dose of 1.5 mg / kg for 90 seconds before fentanyl injection as infusion. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is "There is no more information."
public Hashem Jarineshin
North Mission, Sadeghieh Square
Bandar Abbas Iran (Islamic Republic of) 7915865883 +98 76 3334 5009 drfatemehtaherzadeh@gmail.com Bandare-abbas University of Medical Sciences scientific Hashem Jarineshin
North Mission
Bandar Abbas Iran (Islamic Republic of) 7915865883 +98 76 3334 5009 hjarineshin@gmail.com Bandare-abbas University of Medical Sciences Iran (Islamic Republic of) Patients candidates for elective surgery taking fentanyl. Patients aged 18-65 years Informed consent 18 years 65 years Both Patients taking fentanyl are not candidates for elective surgery. Patients receiving corticosteroids A person with a history of asthma and respiratory diseases in the previous 4 weeks A person with a history of allergies to fentanyl or dexmedetomidine Patients in need of emergency surgery Treatment - Drugs Treatment - Drugs Placebo Intervention group 1: Lidocaine: 1.5 mg / kg intravenously for 90 seconds before fentanyl injection Intervention group: Intervention group 2: Dexmedetomidine: 0.5 μg / kg solution of 10 cc of isotonic saline 10 minutes before anesthesia, by infusion Control group: normal saline at a dose of 1.5 mg / kg for 90 seconds before fentanyl injection as infusion Incidence of cough. Timepoint: Evaluation of cough in patients candidates for elective surgery, two minutes after fentanyl injection. Method of measurement: Cough incidence questionnaire. Intensity of cough. Timepoint: Evaluation of cough severity in patients candidates for elective surgery, two minutes after fentanyl injection. Method of measurement: Cough Intensity Questionnaire. Hormozgan University of Medical Sciences Approved 2021-09-19 Ethics committee of University of Medical Sciences - School of Medicine Imam Hossein Boulevard, Tohid Town Bandarabbas Hormozgan Iran (Islamic Republic of)