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IRCT20180804040695N2 IRCT 2022-02-20 Zanjan University of Medical Sciences The effect of metoprolol on reducing mortality in septic patients Comparison of the Effectiveness of the metoprolol in mortality rate reduction in septic patients admitted to ICU ward 2022-03-21 anticipated 36 Complete https://irct.ir/trial/59575 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Simple randomization using coin toss. Sampling is available and included in the study with the patient's hospitalization, and since we have only two small 18-digit intervention and control groups, assignment to each group is simple random and by tossing coins and taps for each patient, Blinding description: The patient under intervention will be unaware of the type of treatment due to the reduced level of consciousness in the intensive care unit. 2-3 sepsis. Intervention 1: Intervention group: Receiving routine treatment of sepsis in addition to receiving 25 mg oral metoprolol tablets of Alborz Drug Company every eight hours for seven days with regular control of vital signs. Intervention 2: Control group: Receive routine treatment of sepsis. Yes - There is a plan to make this available What will be shared: publishing article When: Over the next year To whom: Public access Conditions: For research Where to obtain: Magazine office How to obtain: Searching in Internet Comments:
public Mohammad Reza Zeraati
Ayatollah Mousavi Specialized and Sub-Specialized Educational and Medical Center, Gavazang Road, Zanjan Town
Zanjan Iran (Islamic Republic of) 4513956184 +98 24 3313 0000 mohammadrezazeraati@zums.ac.ir Zanjan University of Medical Sciences scientific Mohammad Reza Zeraati
Ayatollah Mousavi Specialized and Sub-Specialized Educational and Medical Center, Gavazang Road, Zanjan Town
Zanjan Iran (Islamic Republic of) 4513956184 +98 24 3313 0000 mohammadrezazeraati@zums.ac.ir Zanjan University of Medical Sciences Iran (Islamic Republic of) over 18 y admitted in the ICU wards of Ayatollah Mousavi Hospital in Zanjan Diagnosis of sepsis less than forty-eight hours after diagnosis 18 years no limit Both Pregnancy Acute heart failure AV block bradycardia (heart rate below 70 beats per minute) heart shock hypotension (systolic pressure below 90 mm Hg) pulmonary edema sick sinus syndrome ventricular dysfunction acute bronchospasm asthma bronchitis Chronic Obstructive Pulmonary Disease (COPD) Emphysema Pulmonary Disease Peripheral Artery Disease Raynaud's Phenomenon Vasospastic Angina Brest feeding Pheochromocytoma Myasthenia Gravis Liver Diseases A41 other sepsis Treatment - Drugs Treatment - Drugs Intervention group: Receiving routine treatment of sepsis in addition to receiving 25 mg oral metoprolol tablets of Alborz Drug Company every eight hours for seven days with regular control of vital signs. Control group: Receive routine treatment of sepsis. Mortality rate of septic patients. Timepoint: Two weeks after the start of the intervention. Method of measurement: Refer to the medical file. Heart rate. Timepoint: Every six hours until the end of a week. Method of measurement: cardiac monitoring. Zanjan University of Medical Sciences Approved 2021-10-16 Ethics Committee of Zanjan University of Medical Sciences Zanjan University of Medical Sciences , Azadi Square, Zanjan, Iran Zanjan Zanjan Iran (Islamic Republic of)